Raxatrigine-hydrochloride-GSK-1014802-hydrochloride-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERaxatrigine hydrochlorideCat. No.: HY-12796ACAS No.: 934240-31-0Synonyms: GSK-1014802 hydrochloride; CNV1014802 (hydrochloride)分式: CHClFNO分量: 350.82作靶點: Sodium Channel作通路: Membrane Transporter/Ion Channel儲存式: Powder -20C 3 years

2、4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 31 mg/mL (88.36 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.8505 mL 14.2523 mL 28.5046 mL5 mM 0.5701 mL 2.8505 mL 5.7009 mL10 mM 0.2850 mL 1.4252 mL 2.8505 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備

3、液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Raxatrigine hydrochloride (GSK-1014802 hydrochloride)鈉離通道Nav1.7有效抑制劑。IC50 & Target Sodium channel blocker 1.體外研究Like lamotrigine, both GSK2 and GSK3 were able to prevent the deficit in reversal learning produced by1/2 Master of Small Molecules 您邊的抑制劑師www.MedCh

4、emEPCP, thus confirming their potential in the treatment of cognitive symptoms of schizophrenia. However,higher doses than those required for anticonvulsant efficacy of the drugs were needed for activity in thereversal-learning model, suggesting a lower therapeutic window relative to mechanism-depen

5、dent centralside effects for this indication. Raxatrigine (GSK-1014802) received orphan-drug designation from the USFood and Drug Administration in July 2013.REFERENCES1. Large CH, et al. The efficacy of sodium channel blockers to prevent phencyclidine-induced cognitive dysfunction in the rat: potential fornovel treatments for schizophrenia. J Pharmacol Exp Ther. 2011 Jul;338(1):100-13.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792