ML281-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEML281Cat. No.: HY-13495CAS No.: 1404437-62-2分式: CHNOS分量: 389.47作靶點: Others作通路: Others儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數據體外實驗 DMSO : 30 mg/mL (77.03 mM)H2O : 40% PEG300 5% Tween-80 45% sali

2、neSolubility: 2.5 mg/mL (6.42 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (6.42 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 ML281個強的，有選擇性的STK33抑制劑，IC50值是14 nM。體外研究 ML281 (10 M; 72 hours) suppresses cell viability of NCI-H

3、446 cells 3.Cell Viability Assay 3Cell Line: NCI-H446 cellsConcentration: 10 MIncubation Time: 72 hoursResult: Suppressed cell viability of NCI-H446 cells.戶使本產品發(fā)表的科研獻 Neoplasma. 2017;64(6):869-879.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. We?wer M et al. A Potent and Sele

4、ctive Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-DependentCells. ACS Med Chem Lett, 2012 Dec 13, 3(12):1034-1038.2. Spoonamore J et al. Screen for Inhibitors of STK33 Kinase Activity. National Center for Biotechnology Information (US); 2010-2011 Dec16.3. Sun EL, et

5、 al. Knockdown of human serine/threonine kinase 33 suppresses human small cell lung carcinoma by blocking RPS6/BADsignaling transduction. Neoplasma. 2017;64(6):869-879.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-58955