Nicotinamide-riboside-chloride - Sirtuin Activator - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemENicotinamide riboside chlorideCat. No.: HY-123033ACAS No.: 23111-00-4分式: CHClNO分量: 290.7作靶點: Sirtuin作通路: Cell Cycle/DNA Damage; Epigenetics儲存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromligh

2、t)溶解性數(shù)據(jù)體外實驗 H2O : 250 mg/mL (859.99 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.4400 mL 17.1999 mL 34.3997 mL5 mM 0.6880 mL 3.4400 mL 6.8799 mL10 mM 0.3440 mL 1.7200 mL 3.4400 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Nicotinamide riboside chlo

3、ride是煙酰胺核苷 (Nicotinamide riboside) 氯化物的晶體形式，煙酰胺核苷是煙酰胺腺嘌呤核苷酸 (nicotinamide adenine dinucleotide, NAD +) 前體維素。Nicotinamide ribosidechloride 增加NAD + 平并激活 SIRT1 和 SIRT3，最終增強氧化代謝并防脂 飲誘導(dǎo)的代謝異常。Nicotinamide riboside chloride 于膳補充劑。IC50 & Target SIRT1 SIRT3體外研究Nicotinamide riboside chloride (0.5 nM; 24 hours

4、) reduces the acetylation status of Ndufa9 and SOD2 1.1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEWestern Blot Analysis 1Cell Line: HEK293T cellsConcentration: 0.5 nMIncubation Time: 24 hoursResult: Reduced the acetylation status of Ndufa9 and SOD2.體內(nèi)研究 Chronic Nicotinamide riboside chloride (p

5、.o.; 400 mg/kg/day; for 16 weeks) supplementation increasesplasma and intracellular NAD + content in a tissue-specific manner 1.Animal Model: 10-week-old C57Bl/6J mice 1Dosage: 400 mg/kgAdministration: p.o.; daily; for 16 weeksResult: Increased plasma and intracellular NAD + content in a tissue-spec

6、ific manner.REFERENCES1. Cant C, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protectsagainst high-fat diet-inducedobesity. Cell Metab. 2012 Jun 6;15(6):838-47.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820