AG1024-Tyrphostin-AG-1024-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAG1024Cat. No.: HY-10253CAS No.: 65678-07-1Synonyms: Tyrphostin AG 1024分式: CHBrNO分量: 305.17作靶點: IGF-1R; Autophagy作通路: Protein Tyrosine Kinase/RTK; Autophagy儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解

2、性數(shù)據(jù)體外實驗 DMSO : 50 mg/mL (163.84 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.2769 mL 16.3843 mL 32.7686 mL5 mM 0.6554 mL 3.2769 mL 6.5537 mL10 mM 0.3277 mL 1.6384 mL 3.2769 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制?/p>

3、請先配制澄的儲備液，再依次添加助溶劑(為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (8.19 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 AG-1024 (Tyrphostin)能抑制IGF-1R

4、磷酸化，IC50為7 M，對IR的IC50則為57 M。戶使本產(chǎn)品發(fā)表的科研獻 Biomed Pharmacother. 2017 Nov;95:1346-1358.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Prrizas M, et al. Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function bytyrph

5、ostins. Endocrinology. 1997 Apr;138(4):1427-33.2. Wen B, et al. Tyrphostin AG 1024 modulates radiosensitivity in human breast cancer cells. Br J Cancer. 2001 Dec 14;85(12):2017-21.3. von Willebrand M, et al. The tyrphostin AG1024 accelerates the degradation of phosphorylated forms of retinoblastoma

6、protein (pRb)and restores pRb tumor suppressive function in melanoma cells. Cancer Res. 2003 Mar 15;63(6):1420-9.4. Deutsch E, et al. Tyrosine kinase inhibitor AG1024 exerts antileukaemic effects on STI571-resistant Bcr-Abl expressing cells anddecreases AKT phosphorylation. Br J Cancer. 2004 Nov 1;91(9):1735-41.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 4