Ro-25-6981 - iGluR 抑制劑 - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERo 25-6981Cat. No.: HY-13993CAS No.: 169274-78-6分式: CHNO分量: 339.47作靶點(diǎn): iGluR作通路: Membrane Transporter/Ion Channel; Neuronal Signaling儲(chǔ)存式: Please store the product under the recommended conditions inthe COA.溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 100 m

2、g/mL (294.58 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.9458 mL 14.7288 mL 29.4577 mL5 mM 0.5892 mL 2.9458 mL 5.8915 mL10 mM 0.2946 mL 1.4729 mL 2.9458 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議

3、您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.36 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (7.36 mM); Clear solution3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility

4、: 2.5 mg/mL (7.36 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE物活性 Ro 25-6981是包含NR2B亞基的NMDA受體選擇性阻斷劑，對(duì)于重 組型NR1C/NR2B 和 NR1C/NR2A受體的IC50為0.009 和 52 M。REFERENCES1. Fischer G, et al. Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate recep

5、tors containing the NR2B subunit.Characterization in vitro. J Pharmacol Exp Ther. 1997 Dec;283(3):1285-92.2. Lynch DR, et al. Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit. Eur J Pharmacol.2001 Mar 30;416(3):185-95.3. Jiang M, et al. Antinociception

6、and prevention of hyperalgesia by intrathecal administration of Ro 25-6981, a highly selective antagonistof the 2B subunit of N-methyl-D-aspartate receptor. Pharmacol Biochem Behav. 2013 Nov;112:56-63.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820