Ferrous-bisglycinate-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemEFerrousbisglycinateCat.No.:HY-130078CASNo.:20150-34-9分?式:C?H?FeN?O?分?量:201.95作?靶點(diǎn):Others作?通路:Others儲(chǔ)存?式:4°C,protectfromlight,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light,storedundernitrogen)溶解性數(shù)據(jù)體外實(shí)驗(yàn)H2O:35.71mg/mL(176.83mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM4.9517mL24.7586mL49.5172mL5mM0.9903mL4.9517mL9.9034mL10mM0.4952mL2.4759mL4.9517mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存?式和期限。BIOLOGICALACTIVITY?物活性Ferrousbisglycinate?種具有?服活性的鐵強(qiáng)化劑和補(bǔ)充劑。Ferrousbisglycinate可?于缺鐵性貧?的研究。體外研究Ferrousbisglycinate(25-200μM;2h)doesnotaffecttheCaco-2cellsviability[2].Ferrousbisglycinate(25μM;2h)increasesferritincontentintheCaco-2cells[2].CellViabilityAssay[2]CellLine:Caco-2cells1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemEConcentration:0,25,50,100,200μMIncubationTime:2hoursResult:Didnotaffecttheviabilityofwild-typeanddivalentmetaltransporter1(DMT1)knockoutCaco-2cells.WesternBlotAnalysis[2]CellLine:Caco-2cellsConcentration:25μMIncubationTime:2hoursResult:IncreasedferritincontentanddecreasedDMT1expressionlevelssignificantlyinthewild-typecells.體內(nèi)研究Ferrousbisglycinate(500mg/kgiron;p.o.)exertsaprotectiveeffectoncolitisinmice[3].AnimalModel:FemaleC57BL/6miceareinducedcolitisbydextransodiumsulfate(DSS)[3]Dosage:500mg/kgironAdministration:P.o.(addtothediet)for10daysResult:Hadthebestsurvivalrates(100%).Causedtheleastbodylost(9%bodyloss).REFERENCES[1].FerrariP,et,al.Treatmentofmildnon-chemotherapy-inducedirondeficiencyanemiaincancerpatients:comparisonbetweenoralferrousbisglycinatechelateandferroussulfate.BiomedPharmacother.2012Sep;66(6):414-8.[2].YuX,et,al.IronTransportfromFerrousBisglycinateandFerrousSulfateinDMT1-KnockoutHumanIntestinalCaco-2Cells.Nutrients.2019Feb26;11(3):485.[3].ConstanteM,et,al.IronSupplementsModulateColonMicrobiotaCompositionandPotentiatetheProtectiveEffectsofProbioticsinDextranSodiumSulfate-inducedColitis.InflammBowelDis.2017May;23(5):753-766.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresea