p-p-DDE-4-4-DDE-DataSheet-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemEp,p'-DDECat.No.:HY-B1986CASNo.:72-55-9Synonyms:4,4'-DDE;p,p'-Dichlorodiphenyldichloroethylene分?式:C??H?Cl?分?量:318.03作?靶點:AndrogenReceptor;DrugMetabolite作?通路:Others;MetabolicEnzyme/Protease儲存?式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性數(shù)據(jù)體外實驗DMSO:100mg/mL(314.44mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM3.1444mL15.7218mL31.4436mL5mM0.6289mL3.1444mL6.2887mL10mM0.3144mL1.5722mL3.1444mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存?式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥?式選擇適當?shù)娜芙?案，配制前請先配制澄的儲備液，再依次添加助溶劑(為保證實驗結(jié)果的可靠性，體內(nèi)實驗的?作液，建議您現(xiàn)?現(xiàn)配，當天使?；澄的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分?指該溶劑在您配制終溶液中的體積占?)：1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(7.86mM);Clearsolution2.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(7.86mM);ClearsolutionBIOLOGICALACTIVITY1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemE?物活性p,p'-DDE(4,4'-DDE)持久性DDT的主代謝產(chǎn)物，?種有效的雄激素受體拮抗劑，IC50為5μM，Ki為3.5μM。REFERENCES[1].KelceWR,etal.PersistentDDTmetabolitep,p'-DDEisapotentandrogenreceptorantagonist.Nature.1995;375(6532):581-585.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:02