Validamycin-A-DataSheet-生命科學試劑-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemEValidamycinACat.No.:HY-B0856CASNo.:37248-47-8分?式:C??H??NO??分?量:497.49作?靶點:Fungal;Tyrosinase作?通路:Anti-infection;MetabolicEnzyme/Protease儲存?式:4°C,protectfromlight,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light,storedundernitrogen)溶解性數(shù)據(jù)體外實驗H2O:125mg/mL(251.26mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.0101mL10.0505mL20.1009mL5mM0.4020mL2.0101mL4.0202mL10mM0.2010mL1.0050mL2.0101mL請根據(jù)產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存?式和期限。BIOLOGICALACTIVITY?物活性ValidamycinA?種氨糖苷類農?抗?素。ValidamycinA能抑制曲霉的?長,其MIC值為1μg/mL[1]。ValidamycinA?種可逆的酪氨酸酶抑制劑，其Ki值為5.893mM[2]。IC50&TargetKi:5.893mM(tyrosinase)[2]體外研究ValidamycinA(0.5-1μg/mL;18hours)inhibitsthegrowthofA.flavusanddelayedconidialgermination[1].ValidamycinAshowsnocytotoxicitytohumanbronchialepithelialcells[1].ValidamycinAbindsdirectlytoseveralresiduesintheactivesiteoftyrosinase,includingHIS85,HIS244,1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemEGLU256,HIS259andASN260[1].CellProliferationAssay[1]CellLine:AspergillusflavusATCC204304Concentration:0.5μg/mL,1μg/mLIncubationTime:18hoursResult:InhibitedthegrowthofAspergillusflavus.REFERENCES[1].NapasawanPlabutong,etal.TheInhibitoryEffectofValidamycinAonAspergillusflavus.IntJMicrobiol.2020;2020:3972415.[2].Zhi-JiangWang,etal.TheeffectofvalidamycinAontyrosinase:inhibitionkineticsandcomputationalsimulation.IntJBiolMacromol.2013Apr;55:15-23.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;