感染與心血管疾病課件

感染與心血管疾病

感染與心血管疾病

一、文獻(xiàn)來源二、內(nèi)容簡(jiǎn)介三、分析與討論四、結(jié)論與啟示一、文獻(xiàn)來源一、文獻(xiàn)來源1.Roleofacuteinfectionintriggeringacutecoronarysyndromes.LancetInfectDis2010;10:83–922.InfluenzaandCardiovascularDisease：IsThereaCausalRelationship?TexHeartInstJ.

2004;

31(1):4–13.3.ImmunosuppressiveTreatmentforInflammatoryCardiomyopathy.IntHeartJ2005;46:113-1224.Guidelinesontheprevention,diagnosis,andtreatmentofinfectiveendocarditis(newversion2009).EuropeanHeartJournal(2009)30,2369–2413.5.Efficacyofdaptomycininthetreatmentofenterococcalendocarditis:a5yearcomparisonwithconventionaltherapy.

JAntimicrobChemother.

2014Feb13,PMID:

24532682一、文獻(xiàn)來源1.Roleofacuteinfecti1、感染（infection）系指由細(xì)菌、病毒、真菌、衣原體、支原體、立克次體、螺旋體、原蟲、蠕蟲等病原體所致的疾病。各類病原體可引起多種類型的感染致心血管疾病，使患者健康嚴(yán)重受損和社會(huì)負(fù)荷沉重不堪。2、感染導(dǎo)致心血管疾病以感染性心包炎、感染性心肌炎和感染性心內(nèi)膜炎較常見，而感染性心瓣膜病多由感染性心內(nèi)膜炎引起，感染性血管炎較為少見。3、診治：在盡快留取實(shí)驗(yàn)室檢查標(biāo)本（如疑診感染性心內(nèi)膜炎患者至少抽3次靜脈血進(jìn)行血培養(yǎng)，采血間隔30min～1h）后，應(yīng)根據(jù)循證醫(yī)學(xué)和相關(guān)指南盡早、足量、經(jīng)驗(yàn)性選用抗感染藥物。二、內(nèi)容簡(jiǎn)介1、感染（infection）系指由細(xì)菌、病毒、真菌、衣原體三、分析與討論Roleofacuteinfectionintriggeringacutecoronarysyndromes.

LancetInfectDis2010;10:83–92三、分析與討論RoleofacuteinfectionASeveralmechanismstriggerthedisruptionofanadvancedcoronarylesion.Thedisruptedsurfaceexposesunderlyingthrombogenicmaterial.Plaquedisruptionaloneisnotsu?cientforthedevelopmentofanacutecoronarysyndrome.

BThrombogenicconditions(localandsystemic)determinethrombusformation.CTheocclusivenatureofthethrombus(totalvspartial),thedegreeofstenosis,thepresenceofvasoconstriction,thecoronaryperfusionpressure,andthemyocardialmetabolicbalance(demandvssupply)determinetheevolutionofanacutecoronarysyndrome.ASeveralmechanismstrigger2.InfluenzaandCardiovascularDisease：IsThereaCausalRelationship?TexHeartInstJ.

2004;

31(1):4–13.

2.InfluenzaandCardiovasculaTABLEII.EffectsofInfluenzaontheCoagulationSystemTABLEII.EffectsofInfluenza3.ImmunosuppressiveTreatmentforInflammatoryCardiomyopathy.IntHeartJ2005;46:113-1223.ImmunosuppressiveTreatment感染與心血管疾病課件感染與心血管疾病課件4.Guidelinesontheprevention,diagnosis,andtreatmentofinfectiveendocarditis(newversion2009).EuropeanHeartJournal(2009)30,2369–2413.4.Guidelinesontheprevention感染性心內(nèi)膜炎的臨床表現(xiàn)感染性心內(nèi)膜炎的臨床表現(xiàn)感染性心內(nèi)膜炎的診斷標(biāo)準(zhǔn)感染性心內(nèi)膜炎的診斷標(biāo)準(zhǔn)感染與心血管疾病課件5.Efficacyofdaptomycininthetreatmentofenterococcalendocarditis:a5yearcomparisonwithconventionaltherapy.

JAntimicrobChemother.

2014，13：PMID:

24532682Enterococcusspp.accountfor10%ofinfectiveendocarditis(IE)AlthoughdaptomycinisabactericidaldrugwithinvitroactivityagainstEnterococcus,thereislittleexperienceofitsuseinIE.Thiswasaretrospectivedescriptivestudycomparingtheef?cacyofdaptomycinversusampicillin/ceftriaxoneversusconventionalantibioticregimens(ampicillinorvancomycin+gentamicin)inEIE5.EfficacyofdaptomycinintTable1.Baselinecharacteristicsofthe32patientswithenterococcalinfectiveendocarditisdiagnosedduringthestudyperiodTable1.Baselinecharacterist感染與心血管疾病課件1、感染引起心血管疾病的確診比較困難，并且往往較晚，起始經(jīng)驗(yàn)治療對(duì)患者預(yù)后有著重要意義。2、病毒性心肌炎以對(duì)癥支持治療為主。雖然免疫參與了病程進(jìn)展，但是抑制免疫的藥物并不能改善患者的預(yù)后。3、根據(jù)ESC及BSAC指南，重癥感染性心內(nèi)膜炎起始經(jīng)驗(yàn)治療可啟用萬古霉素聯(lián)合慶大霉素等。4、達(dá)托霉素單獨(dú)治療EIE，療效并不優(yōu)于上述傳統(tǒng)治療方案。四、結(jié)論與啟示1、感染引起心血管疾病的確診比較困難，并且往往較晚，起始經(jīng)驗(yàn)謝謝DepartmentofMacromolecularScience--FudanUniversity謝謝DepartmentofMacromolecular后面內(nèi)容直接刪除就行資料可以編輯修改使用資料可以編輯修改使用后面內(nèi)容直接刪除就行主要經(jīng)營(yíng)：網(wǎng)絡(luò)軟件設(shè)計(jì)、圖文設(shè)計(jì)制作、發(fā)布廣告等公司秉著以優(yōu)質(zhì)的服務(wù)對(duì)待每一位客戶，做到讓客戶滿意！主要經(jīng)營(yíng)：網(wǎng)絡(luò)軟件設(shè)計(jì)、圖文設(shè)計(jì)制作、發(fā)布廣告等致力于數(shù)據(jù)挖掘，合同簡(jiǎn)歷、論文寫作、PPT設(shè)計(jì)、計(jì)劃書、策劃案、學(xué)習(xí)課件、各類模板等方方面面，打造全網(wǎng)一站式需求致力于數(shù)據(jù)挖掘，合同簡(jiǎn)歷、論文寫作、PPT設(shè)計(jì)、計(jì)劃書、策劃感謝您的觀看和下載Theusercandemonstrateonaprojectororcomputer,orprintthepresentationandmakeitintoafilmtobeusedinawiderfield感謝您的觀看和下載Theusercandemonstr感染與心血管疾病

感染與心血管疾病

一、文獻(xiàn)來源二、內(nèi)容簡(jiǎn)介三、分析與討論四、結(jié)論與啟示一、文獻(xiàn)來源一、文獻(xiàn)來源1.Roleofacuteinfectionintriggeringacutecoronarysyndromes.LancetInfectDis2010;10:83–922.InfluenzaandCardiovascularDisease：IsThereaCausalRelationship?TexHeartInstJ.

2004;

31(1):4–13.3.ImmunosuppressiveTreatmentforInflammatoryCardiomyopathy.IntHeartJ2005;46:113-1224.Guidelinesontheprevention,diagnosis,andtreatmentofinfectiveendocarditis(newversion2009).EuropeanHeartJournal(2009)30,2369–2413.5.Efficacyofdaptomycininthetreatmentofenterococcalendocarditis:a5yearcomparisonwithconventionaltherapy.

JAntimicrobChemother.

2014Feb13,PMID:

24532682一、文獻(xiàn)來源1.Roleofacuteinfecti1、感染（infection）系指由細(xì)菌、病毒、真菌、衣原體、支原體、立克次體、螺旋體、原蟲、蠕蟲等病原體所致的疾病。各類病原體可引起多種類型的感染致心血管疾病，使患者健康嚴(yán)重受損和社會(huì)負(fù)荷沉重不堪。2、感染導(dǎo)致心血管疾病以感染性心包炎、感染性心肌炎和感染性心內(nèi)膜炎較常見，而感染性心瓣膜病多由感染性心內(nèi)膜炎引起，感染性血管炎較為少見。3、診治：在盡快留取實(shí)驗(yàn)室檢查標(biāo)本（如疑診感染性心內(nèi)膜炎患者至少抽3次靜脈血進(jìn)行血培養(yǎng)，采血間隔30min～1h）后，應(yīng)根據(jù)循證醫(yī)學(xué)和相關(guān)指南盡早、足量、經(jīng)驗(yàn)性選用抗感染藥物。二、內(nèi)容簡(jiǎn)介1、感染（infection）系指由細(xì)菌、病毒、真菌、衣原體三、分析與討論Roleofacuteinfectionintriggeringacutecoronarysyndromes.

LancetInfectDis2010;10:83–92三、分析與討論RoleofacuteinfectionASeveralmechanismstriggerthedisruptionofanadvancedcoronarylesion.Thedisruptedsurfaceexposesunderlyingthrombogenicmaterial.Plaquedisruptionaloneisnotsu?cientforthedevelopmentofanacutecoronarysyndrome.

BThrombogenicconditions(localandsystemic)determinethrombusformation.CTheocclusivenatureofthethrombus(totalvspartial),thedegreeofstenosis,thepresenceofvasoconstriction,thecoronaryperfusionpressure,andthemyocardialmetabolicbalance(demandvssupply)determinetheevolutionofanacutecoronarysyndrome.ASeveralmechanismstrigger2.InfluenzaandCardiovascularDisease：IsThereaCausalRelationship?TexHeartInstJ.

2004;

31(1):4–13.

2.InfluenzaandCardiovasculaTABLEII.EffectsofInfluenzaontheCoagulationSystemTABLEII.EffectsofInfluenza3.ImmunosuppressiveTreatmentforInflammatoryCardiomyopathy.IntHeartJ2005;46:113-1223.ImmunosuppressiveTreatment感染與心血管疾病課件感染與心血管疾病課件4.Guidelinesontheprevention,diagnosis,andtreatmentofinfectiveendocarditis(newversion2009).EuropeanHeartJournal(2009)30,2369–2413.4.Guidelinesontheprevention感染性心內(nèi)膜炎的臨床表現(xiàn)感染性心內(nèi)膜炎的臨床表現(xiàn)感染性心內(nèi)膜炎的診斷標(biāo)準(zhǔn)感染性心內(nèi)膜炎的診斷標(biāo)準(zhǔn)感染與心血管疾病課件5.Efficacyofdaptomycininthetreatmentofenterococcalendocarditis:a5yearcomparisonwithconventionaltherapy.

JAntimicrobChemother.

2014，13：PMID:

24532682Enterococcusspp.accountfor10%ofinfectiveendocarditis(IE)AlthoughdaptomycinisabactericidaldrugwithinvitroactivityagainstEnterococcus,thereislittleexperienceofitsuseinIE.Thiswasaretrospectivedescriptivestudycomparingtheef?cacyofdaptomycinversusampicillin/ceftriaxoneversusconventionalantibioticregimens(ampicillinorvancomycin+gentamicin)inEIE5.EfficacyofdaptomycinintTable1.Baselinecharacteristicsofthe32patientswithenterococcalinfectiveendocarditisdiagno