Acetylene-linker-Val-Cit-PABC-MMAE-LCB14-0602-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEAcetylene-linker-Val-Cit-PABC-MMAECat.No.:HY-19812CASNo.:1411977-95-1Synonyms:LCB14-0602分?式:C??H???N??O??分?量:1307.62作?靶點(diǎn):Drug-LinkerConjugatesforADC作?通路:Antibody-drugConjugate/ADCRelated儲(chǔ)存?式:4°C,storedundernitrogen*該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)?現(xiàn)配，即刻使?。溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:50mg/mL(38.24mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM0.7647mL3.8237mL7.6475mL5mM0.1529mL0.7647mL1.5295mL10mM0.0765mL0.3824mL0.7647mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液；該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)?現(xiàn)配，即刻使?.體內(nèi)實(shí)驗(yàn)請根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥1.25mg/mL(0.96mM);Clearsolution2.請依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥1.25mg/mL(0.96mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE3.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥1.25mg/mL(0.96mM);ClearsolutionBIOLOGICALACTIVITY?物活性Acetylene-linker-Val-Cit-PABC-MMAE(LCB14-0602)由ADClinker(Acetylene-linker-Val-Cit-PABC)和MMAE組成，MMAE?種有效的微管(tubulin)抑制劑。Acetylene-linker-Val-Cit-PABC-MMAE(LCB14-0602)可?于偶聯(lián)抗體。IC50&TargetAuristatinREFERENCES[1].PROTEIN-ACTIVEAGENTCONJUGATESANDMETHODFORPREPARINGTHESAME.WIPOPatentApplicationWO/2012/153193.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>