16-16-Dimethyl-prostaglandin-E2-16-16-dimethyl-PGE2-DataSheet-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemE16,16-DimethylprostaglandinE2Cat.No.:HY-106420CASNo.:39746-25-3Synonyms:16,16-dimethylPGE2分?式:C??H??O?分?量:380.52作?靶點:ProstaglandinReceptor作?通路:GPCR/GProtein儲存?式:Pureform-20°C3yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:100mg/mL(262.80mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.6280mL13.1399mL26.2798mL5mM0.5256mL2.6280mL5.2560mL10mM0.2628mL1.3140mL2.6280mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。體內(nèi)實驗請根據(jù)您的實驗動物和給藥?式選擇適當?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實驗結(jié)果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當保存；體內(nèi)實驗的?作液，建議您現(xiàn)?現(xiàn)配，當天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(6.57mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE2.請依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(6.57mM);Clearsolution3.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(6.57mM);ClearsolutionBIOLOGICALACTIVITY?物活性16,16-DimethylprostaglandinE2(16,16-dimethylPGE2)?種具有?服活性的脊椎動物造??細胞(HSCs)穩(wěn)態(tài)關(guān)鍵調(diào)節(jié)劑。16,16-DimethylprostaglandinE2可以通過EP2/EP4起作?，并與Wnt途徑相互作?。體內(nèi)研究16,16-DimethylprostaglandinE2(16,16-dimethylPGE2;10μg/kg;i.p.;every12hours;for8days)rescuestheexacerbatedDSScolitisphenotypeofTpl2IMF-KOmiceandrestoresepithelialproliferationandstructure[2].AnimalModel:Tpl2IMF-KOmice[2]Dosage:10μg/kgAdministration:IP;every12hours;for8daysResult:RescuedtheexacerbatedDSScolitisphenotypeandrestoresepithelialproliferationandstructure.REFERENCES[1].HagedornEJ,etal.Gettingmoreforyourmarrow:boostinghematopoieticstemcellnumberswithPGE2.xpCellRes.2014Dec10;329(2):220-6.[2].RoulisM,etal.Intestinalmyofibroblast-specificTpl2-Cox-2-PGE2pathwaylinksinnatesensingtoepithelialhomeostasis.ProcNatlAcadSciUSA.2014Oct28;111(43):E4658-67.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonl