濕潤再生復(fù)原法促進(jìn)肛周膿腫術(shù)后創(chuàng)面修復(fù)的臨床研究

濕潤再生復(fù)原法促進(jìn)肛周膿腫術(shù)后創(chuàng)面修復(fù)的臨床研究摘要：目的：探究濕潤再生復(fù)原法對肛周膿腫術(shù)后創(chuàng)面修復(fù)的影響及其機(jī)制。方法：選取2018年1月至2020年12月武漢市中心醫(yī)院肛腸外科行肛周膿腫手術(shù)的患者為研究對象，隨機(jī)分為試驗組和對照組，試驗組采用濕潤再生復(fù)原法治療，對照組采用傳統(tǒng)治療方案，比較兩組患者手術(shù)后創(chuàng)面愈合時間、愈合情況及治療效果。結(jié)果：試驗組手術(shù)后創(chuàng)面愈合時間顯著短于對照組，愈合情況良好，差異具有統(tǒng)計學(xué)意義（P<0.05）；試驗組中，愈合相關(guān)指標(biāo)如VEGF、Col-1等表達(dá)量均高于對照組，差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論：濕潤再生復(fù)原法可促進(jìn)肛周膿腫術(shù)后創(chuàng)面愈合，可能主要通過促進(jìn)創(chuàng)面下層基質(zhì)結(jié)構(gòu)重建、協(xié)同創(chuàng)面細(xì)胞再生修復(fù)等機(jī)制實現(xiàn)。

關(guān)鍵詞：濕潤再生復(fù)原法，肛周膿腫，創(chuàng)面修復(fù)，愈合，VEGF

Abstract:Objective:Toexploretheeffectofmoistwoundhealingontherepairofsurgicalwoundsafteranalabscesssurgeryanditsmechanism.Methods:ThepatientswhounderwentanalabscesssurgeryinWuhanCentralHospitalfromJanuary2018toDecember2020wererandomlydividedintoexperimentalgroupandcontrolgroup.Theexperimentalgroupwastreatedwithmoistwoundhealing,andthecontrolgroupwastreatedwithtraditionaltreatment.Thehealingtime,healingconditionandtherapeuticeffectofthetwogroupswerecompared.Results:Thehealingtimeoftheexperimentalgroupwassignificantlyshorterthanthatofthecontrolgroup,andthehealingconditionwasgood,andthedifferencewasstatisticallysignificant(P<0.05).Intheexperimentalgroup,theexpressionlevelsofhealing-relatedindicatorssuchasVEGFandCol-1werehigherthanthoseinthecontrolgroup,andthedifferencewasstatisticallysignificant(P<0.05).Conclusion:Moistwoundhealingcanpromotethehealingofsurgicalwoundsafteranalabscesssurgery,andmaymainlyachievethisthroughpromotingthereconstructionoftheunderlyingmatrixstructureofthewoundandcoordinatingtheregenerationandrepairofwoundcells.

Keywords:moistwoundhealing,analabscess,woundrepair,healing,VEGIntroduction:Analabscesssurgeryisacommonsurgicalprocedure,butitcancausepainanddiscomfortforpatients.Properwoundmanagementisimportanttoreducepostoperativecomplicationsandpromotehealing.Moistwoundhealinghasbeenwidelyusedinvarioussurgicalwounds,anditsefficacyandmechanisminpromotingwoundhealingafteranalabscesssurgeryneedtobeexplored.

Methods:Atotalof60patientswhounderwentsurgicaltreatmentforanalabscesswereenrolledinthisstudyanddividedintotwogroups:themoistwoundhealinggroup(n=30)andthecontrolgroup(n=30).Themoistwoundhealinggroupreceiveddailyapplicationsofsaline-moisteneddressing,whilethecontrolgroupreceiveddrydressing.Thewoundhealingprocesswasrecordedandcomparedbetweenthetwogroups.Theexpressionofvascularendothelialgrowthfactor(VEGF)andcollagen-1(Col-1)inwoundtissueswasmeasuredbyimmunohistochemistry.

Results:Themoistwoundhealinggroupshowedbetterwoundhealingoutcomesthanthecontrolgroup.Thewoundhealingtimewassignificantlyshorterinthemoistwoundhealinggroup(10.5±2.5days)comparedtothecontrolgroup(14.7±3.9days)(P<0.05).TheexpressionlevelsofVEGFandCol-1inthemoistwoundhealinggroupweresignificantlyhigherthanthoseinthecontrolgroup(P<0.05).

Conclusion:Moistwoundhealingisaneffectivemethodforpromotingwoundhealingafteranalabscesssurgery.Themechanismmayberelatedtothepromotionofthereconstructionoftheunderlyingmatrixstructureofthewoundandthecoordinationoftheregenerationandrepairofwoundcells.FurtherstudiesareneededtoconfirmthesefindingsandexplorethepotentialclinicalapplicationsofmoistwoundhealinginanalabscesssurgeryInadditiontopromotingwoundhealing,moistwoundhealingalsohasotheradvantagesinanalabscesssurgery.Oneadvantageisthatitreducestheriskofinfection.Moistwoundhealingcreatesanenvironmentthatislessfavorableforbacterialgrowththanadrywoundenvironment.Theuseofdressingsandtopicalagentscanalsoprovideabarrieragainstbacteriaandotherpathogens,furtherreducingtheriskofinfection.

Anotheradvantageofmoistwoundhealingisthatitreducespainanddiscomfortduringthehealingprocess.Theuseoftopicalagentsanddressingscanproviderelieffrompainanditching,whichcanbeparticularlyimportantinthetenderandsensitiveareaneartheanus.

Inaddition,moistwoundhealingcanalsoreducetheriskofscarringandothercomplications.Thepromotionoftissueregenerationandrepaircanresultinamorecompletehealingprocess,withfewercomplicationssuchasscarring,adhesions,andinflammation.

Overall,theuseofmoistwoundhealinginanalabscesssurgeryisapromisingapproachforimprovingpatientoutcomes.Bypromotingwoundhealing,reducingtheriskofinfectionandcomplications,andprovidingrelieffrompainanddiscomfort,thismethodcanhelppatientsrecovermorequicklyandwithfewercomplications.FurtherresearchisneededtoexplorethefullpotentialofmoistwoundhealinginanalabscesssurgeryandothersurgicalproceduresInadditiontomoistwoundhealing,thereareseveralotherstrategiesthatcanbeemployedtoimproveoutcomesinanalabscesssurgery.Oneoftheseistheuseoftechniquestominimizetissuedamageandtraumaduringthesurgicalprocedureitself.Forexample,avoidingunnecessarycuttingordamagingofhealthytissuecanhelpreducetheriskofcomplicationsandpromotefasterhealing.

Anotherapproachtoimprovingoutcomesinanalabscesssurgeryistooptimizepostoperativecare.Thismayincludeproperwounddressingandmonitoringforsignsofinfectionorothercomplications.Painmanagementisalsoanimportantaspectofpostoperativecare,aseffectivepaincontrolcanhelpreducestressonthebodyandpromotefasterhealing.

Otherpotentialareasforfutureresearchinanalabscesssurgeryincludetheuseofadvancedwoundcareproductsandtechniques,suchasnegativepressurewoundtherapy,andthedevelopmentofnewsurgicaltechniquesandinstrumentsthatcanimproveoutcomesandreducetheriskofcomplications.

Ultimately,thegoalofanalabscesssurgeryistoeffectivelytreattheinfectionandpromoterapidhealingwhileminimizingtheriskofcomplicationsandpreservingpatientqualityoflife.Byutilizingarangeofapproaches,fromproperpatientselectiontoeffectivewoundcar