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1、分享兩篇SCI發(fā)表的經(jīng)歷三年前對于我來說SCI就是天書一樣,在我踏進博士的門檻后我以為自己進入了地獄,也糾結(jié)也彷徨,整天刷蟲友們對于博士、SCI的帖子,我選擇了蟲友們鼓勵的那一局部來鼓勵自己繼續(xù)前行。我告訴自己堅持就是勝利,當然那是積極的堅持。在好幾月之前就有這個想法,今天早上收到第二篇的接收通知后,我便想今天一定要在小木蟲上謝謝那些給予我?guī)椭南x友們。 話不多說,我把自己這兩篇投稿的經(jīng)歷與大家共享,希望能給大家?guī)硪稽c點用處。第一篇發(fā)表在FitoterapiaCover letterDear Editor Verotta:We would like to submit the manuscr

2、ipt entitled "××××××題目" by ××××××所有作者which we wish to be considered for publication in Journal of Fitoterapia.All authors have read and approved this version of the article, and due care has been taken to ensure the integrity of t

3、he work. Neither the entire paper nor any part of its content has been published or has been accepted elsewhere. It is not being submitted to any other journal. We believe the paper may be of particular interest to the readers of your journal as it is the first time of ××××&

4、#215;×研究的精華所在Thank you very much for your reconsidering our revised manuscript for potential publication in Fitoterapia. We are looking forward to hearing from you soon. Correspondence should be addressed to Jinhui Yu at the following address, phone and fax number, and email address.地址、 學(xué)院、學(xué)校名稱

5、Phone: + 86××××××Fax number: + 86571××××××Email address: ××××××163 Best wishes for you and your family!Sincerely yours,×××所有作者Response to reviewersDear Editor:Thank you very much for your letter

6、and the comments from the referees about our paper submitted to Journal of Fitoterapia (FITOTE-D-11-01071). The manuscript entitled "××××××" by ××××××所有作者 have been revised according to the reviewers comments, and we wish it to be

7、 reconsidered for publication in Journal of Fitoterapia.A list of changes and responses to reviewers are as follows.List of ActionsLOA1: The key words were changed in page?.LOA2: The name and location of the local biochemistry company have been added in section 2.1 (page 3).LOA3: A paragraph has bee

8、n added in section 3.1 (page 5) to further explain the determination of the cis and trans configuration of double bonds in polyprenols.LOA4: The language was improved by English language editing of Elsevier webshop.To Reviewer 1#,Thank you very much for pointing out the problems in our manuscript. W

9、e have revised it according to your recommendations. We would like to know if there are still somewhere need to be amended. (1) Keywords: general terms should be avoided; I would change some of the keywords (homologues, identification, quantification)The key words have been changed as follows:

10、××××××修改后關(guān)鍵詞(2) In paragraph 2.1 the "local biochemistry company" should be identified by name and location.The name and location of the local biochemistry company have been added in section 2.1 (page 3). NaOH,Pyrogallol,anhydrous Na2SO4 were purchased from Ha

11、ngzhou ChangqingHuagong CO., LTD.(3) How the cis and trans configuration of double bonds in ×××××× were determined? Authors should say something about.The following paragraph has been added in section 3.1 (page 5) to further explain the determination of the cis and tran

12、s configuration of double bonds in ××××××.(4) Language should be checked for clarity and correctness.The language was improved by English language editing of Elsevier webshop.To Reviewer 2#,Thank you very much for your recommendation on our paper and we have improved by

13、 English language editing of Elsevier webshop. All in all, thank you very much for your reconsidering our revised manuscript for potential publication in Fitoterapia. I'm looking forward to hearing from you soon. Correspondence should be addressed to *第一作者或通訊作者at the following address, phon

14、e and fax number, and email address.地址Phone: + 86571××××××Fax number: + ××××××Email address: ××××××163 Best wishes for you and your family!Sincerely yours,××××××所有作者總的來說,第一篇文章沒有費很大

15、勁。投稿后二個月左右便有消息,小修后提交,第二天便接收了!那是因為這篇文章是歷經(jīng)磨難后的,之前投了和,其中第一個期刊當天就給我回復(fù)了,那肯定是悲劇的!編輯所謂的與該期刊不符,但我認為主要是因為文章寫的太垃圾,那是我第一次寫而且是沒有任何人指點的情況下,可想而知會有多爛。隨后這篇文章放了將近一年,填補了寫數(shù)據(jù),又投了第二個期刊,編輯委婉的拒了但給我修改重投的時機。我按照審稿人的意見和建議修改了幾個月后重投補數(shù)據(jù),重新整結(jié)構(gòu)框架,僅次于重寫,結(jié)果悲劇了。而且不是因為修改的問題,而是說我的文章檔次太低,缺乏以在上發(fā)表,我當時暈倒怎么不早說,害我這么長時間的重修。不過現(xiàn)在想想假設(shè)不是重修在下次的投稿中

16、又怎能如此順利呢?所以說所有的努力都不是白費的!第二篇投了Journal of Ethnopharmacology,相比第一篇這個稍有磨難。也是差不多兩個月的樣子收到修改意見,修改后提交一直不見動靜,等兩個月左右的時候我有點不住了,編發(fā)了一封催稿信,之前看論壇里說忌諱催稿,但也看期刊吧,Journal of Ethnopharmacology的編輯第二天便給了修改建議還是要修改,原因是第一次修改是一個審稿人的,由于另外一個審稿人一直沒給才拖到第二次。也沒方法,只能再改!這次相比照擬快點,每到一個月便通知接收了。Journal of Ethnopharmacology與別的期刊不同,有一份Aut

17、hor_checklist。不算重要但還是給大家附上附件吧黏貼好似亂掉了,我之前也是請教的蟲友。需要提醒的是初次提交和修改后要注意最后一項打勾。Dear editor,We would like to submit the manuscript entitled " ××××××" by ×××××× which we wish to be considered for publication in Journal of Ethnopharmacology

18、.All authors have read and approved this version of the article, and due care has been taken to ensure the integrity of the work. Neither the entire paper nor any part of its content has been published or has been accepted elsewhere. It is not being submitted to any other journal. We believe th

19、e paper may be of particular interest to the readers of your journal as it is the first time of investigating ××××××Correspondence should be addressed to Jinhui Yu at the following address, phone and fax number, and email address.地址Phone: + 86××××

20、15;×Fax number: + 86571××××××Email address: ××××××163 Thank you very much for your considering our manuscript for potential publication. I'm looking forward to hearing from you soon.Best wishes for you and your family!Sincerely you

21、rs,××××××大同小異 單獨提交第一次修改A list of changes and responses to reviewers are as follows.List of ActionsLOA1: The reference on the selection of doses has been adapted in section 2.2 (page 5).LOA2: The details of HPLC data were supplemented in section 2.1 (page 4).LOA3: F

22、igure 3, figure 4 and figure 5 have been redrawn. Replies to the remarks of the reviewer 1:The authors appreciate valuable suggestions and comments from the anonymous reviewers. We have revised our manuscript accordingly. Hope it is satisfactory now.(1) How the doses have been selected? If the

23、doses have been adapted from a previous publication please cite the paper. The doses were selected according to previous studies of ××××××。 We have adapted the paper in our revised manuscript. (2) It would be more interesting if the authors could show the deta

24、ils of HPLC data in this manuscript. Which fraction has been used to perform experiments?We have provided the HPLC chromatogram of ×××××× used in the animal experiment. The fraction of the purified extract mostly consisted of ××××××, which

25、accounting for 0.22%, 1.06%, 5.65%, 13.96%, 10.82%, 6.70%, 14.47%, 22.81%, 16.64%, 6.13%, 1.52%, respectively. The purity of the ×××××× was assessed using HPLC, amounting to > 85%. (3) Fig 3 and 5 should be redone. Photos may take by using little more higher obj

26、ectives like 32X or 40 X to show the picture clearly. Scale bars should be mentioned inside the figure (in right corner).We redrew the both figures. Scale bars have been mentioned inside the figure 3, figure 4 and figure 5. The magnification of 200× was adopted for figure 3 and figure 5, referr

27、ing to many previous studies (Gui et al., 2006; Hsieh et al., 2021; Jung et al., 2021; Xiao et al., 2021). The reviewer's concern about the insufficiently clear figures might result from the low resolution of the picture in our previous version. Corresponding pictures with improved resolution we

28、re provided, which appear much clearer. We can also provide original figures if it is necessary.References:Gui, S.Y., Wei, W., Wang, H., Wu, L., Sun, W.Y., Chen, W.B. and Wu, C.Y., 2006. Effects and mechanisms of crude astragalosides fraction on liver fibrosis in rats. Journal of Ethnopharmacology 1

29、03: 154-159.Hsieh, W.T., Liu, Y.T. and Lin, W.C., 2021. Anti-inflammatory properties of Ajuga bracteosa in vivo and in vitro study and their effects on mouse model of liver fibrosis. Journal of Ethnopharmacology 135: 116-125.Jung, H.W., Jung, J.K., Son, K.H., Lee, D.H., Kang, T.M., Kim, Y.S. and Par

30、k, Y.K., 2021. Inhibitory effects of the root extract of Dipsacus asperoides C.Y. Cheng et al t.m.ai on collagen-induced arthritis in mice. Journal of Ethnopharmacology 139: 98-103.Xiao, J., Liong, E.C., Ching, Y.P., Chang, R.C., So, K.F., Fung, M.L. and Tipoe, G.L., 2021. Lycium barbarum polysaccha

31、rides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation. Journal of Ethnopharmacology 139: 462-470.Yu, J., Wang, Y., Qian, H., Zhao, Y., Liu, B. and Fu, C. Polyprenols from the needles of Taxus chinensis var. mairei. Fitoterapia, in revison.第二次修改A list of ch

32、anges and responses to reviewers are as follows.List of ActionsLOA1: The description of the effect of TPs (protective rather than therapeutic) in the article was corrected to avoid misunderstanding. Introduction, the last sentence (paragraph 3).Section 3.1, “Rats treated with TPs was changed as

33、 “Rats treated with both TPs and CCl4 (line 3)Section 3.5, “in the livers of chronic CCl4 treated rats was deleted by adding “In the treatment with TPs+CCl4 at the head of the sentence. (line 7)Discussion, the first and the last sentence (paragraph 1).Discussion, “the treatment with TPs was changed

34、as “the treatment with TPs+CCl4(paragraph 2, line 9)Discussion, the last sentence (paragraph 4)Discussion, the last sentence (paragraph 5)Discussion, the first sentence (paragraph 7)LOA2: The figures and tables are explained in order in the main text. Section 3.1, Fig. 3A (line 6) was added.Sec

35、tion 3.3, Fig. 4A (line 2), Fig. 4B-C (line 3) and Fig. 4B (line 9) and Fig. 4A-B (line 10) were deleted.Section 3.4, Fig. 5A, F (line 3), Fig. 5C-E, F (line 5) were added. LOA3: Figure 2 was supplemented with the standard chromatogram and concrete information about the peaks under the figure.&

36、#160;LOA4: The petroleum was corrected into petroleum ether.LOA5: The discussion section was modified.Replies to the remarks of the reviewer 2:The authors appreciate valuable suggestions and comments from the anonymous reviewers. We have revised our manuscript accordingly.1. Fig 6 shows that ×&

37、#215;×××× on RNA expression is not dose dependent, rather different doses of ×××××× has opposite effect ( Fig 6 A, E,K), means that protein level of this gene could provide the missing links. According to me protein level along with RNA level could p

38、rovide an insight to the mechanism of ××××××.        We agree with this point. We have actually tried quantitative analyses of relative proteins to further clarify mechanism, as well as Western-Blot experiments. These efforts, however, failed due to

39、the technical difficulty of removing the lipid composition which seriously interfere the accuracy of protein quantification. After the optimization and improvement of the extraction for quite a long time, the experimental result was still not satisfactory. However, we believe our present results cou

40、ld fairly although not perfectly support our main conclusions. Anyway, we changed several interpretations of the present results to adequately discuss the mechanisms of ××××××。2. In the conclusion, the authors claimed that " the possible mechanism involves an anti

41、oxidative ability.". According to the Table 4 data, it is evident that lipid peroxidation of ×××××× 120 and 300 are same ( insignificantly different) but corresponding antioxidant enzyme activities were significantly differ between them.       

42、The inconsistent results between antioxidant enzyme activities and lipid peroxidation might need some explanation. As we know, the composition of the lipid peroxidation which includes many other components (Loidl-Stahlhofen and Spiteller, 1994) except malondialdehyde might have been changed under &#

43、215;××××× 300 treatment. Moreover, the antioxidant mechanism of different drugs in various organisms is completed according to previous studies (Galano et al., 2021; Qian et al., 2021). We just speculate that the anti-fibrotic effect might be related with the antioxidant abi

44、lity of the ×××××× based on the data, while the preliminary conclusion needs further experimental verifications. We have made corresponding modification on the conclusion in our manuscript. 3. I am confused with the duration of ××××××

45、in animals. Induction of cirrhosis was done by subcutaneous injection of CCl4 for 8weeks. Simultaneous administration of drug was performed for 8weeks. Can I assume that the action of drug is to prevent the induction of cirrhosis rather than therapeutic effect?The experiment only verified the preven

46、tive effect rather than the therapeutic effect. We will consider the therapeutic effect in the next experiment. We have corrected the description in the article to avoid misunderstanding4. The figures and Tables are not explained in order, in the main text.We have carefully checked the whole text an

47、d corrected the issues you raised. 5. Fig 2, chromatogram of standard is missing, explanation of different peaks are also missingWe have supplied the standard chromatogram in Figure 2, and appended the particular information of each peak, including the name of the substance and the percentage.6

48、. Expression of "p value" is misleadingWe are sorry that we have not comprehended your meaning. The expression of "p value" in our manuscript was referred to literatures (Kim et al., 2021; Li et al., 2021). 7. In the method section, instead of petroleum, petroleum ether woul

49、d give better perception.We are sorry about the mistake. Actually, we used petroleum ether in the experiment.8. Tests like Indocyanine green plasma disappearance rate/ monoethylglycinexylidide test would be more sensitive tests for liver functionWe selected the indicators and methods for liver funct

50、ion evaluation according to the published literature on animal experiments (Li et al., 2021; Mu et al., 2021; Takahashi et al., 2021; Tipoe et al., 2021). They are also well accepted as indicators in this field. Indocyanine green plasma disappearance rate/monoethylglycinexylidide test are mainly in

51、clinical use. We will consider its application in our further studies.9. The mechanism of ×××××× is not properly discussed.We have endeavored to sort out the mechanism of ×××××× via further revision of the corresponding discussion. The auth

52、ors would appreciate that reviewers could explicitly state the points in case of further concerns. We promise to address them immediately.10.  Authors suggested in the limitation of the study that ×××××× is not higly pure, still it shows better activity than s

53、tandard drug, not in histopathology results.Thanks for highlighting our findings. ×××××× are promising natural products deserving further investigations. Actually we are currently optimizing the purified process to prepare high-purity ×××××× for post verification experiment. References:Galano, A., álvarez-Diduk, R., Ramírez-Silva, M.T., Alarcón-ángeles, G. and Rojas-Hernández, A., 2021. Role of the rea

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