診斷增生性腸炎

1、診斷增生性腸炎診斷增生性腸炎 一、 概念 豬增生性腸炎又稱增生性腸病，是小腸和結(jié)腸黏膜增生形成腸腺瘤樣結(jié)構(gòu)，又稱為腸腺瘤病或回腸炎。二、 病原及發(fā)病機理（一）病原： 病原為專性細(xì)胞內(nèi)寄生菌，又稱勞氏細(xì)胞內(nèi)菌（lawsons）。Ileitis - Warthin-Starry silver stain 回腸炎：沃斯銀染Lawsonia intracellularis in apical cytoplasma of crypt cells.Lawsonia intracellularis （細(xì)胞內(nèi)羅松氏菌）隱窩細(xì)胞胞漿上方的病原Ileitis - Warthin Starry stain回腸炎：沃

2、斯銀染curved intracellular Lawsonia organisms. 彎曲的細(xì)胞內(nèi)羅松氏菌（二）發(fā)病機理： 腸道感染后8-10天即可出現(xiàn)病變，21天時病變達(dá)到高峰，使腸道黏膜陷窩上皮增生形成腺瘤樣結(jié)構(gòu)，病豬表現(xiàn)為消瘦和不規(guī)律腹瀉。 三、病理變化（一）急性出血性回腸炎。Normal正常villi destroyed損傷的絨毛Ileitis 血糞，黑糞豬下痢Ileitis - dark colonic and cecal content回腸炎黑色的結(jié)腸盲腸內(nèi)容物Ileitis 回腸炎出血Ileitis with regional, segmental distribution回腸

3、炎界線明顯的病變（二）回腸壞死性腸炎。纖維壞死性腸炎，隱窩擴張，分支，增生Crypt proliferation and absence of goblet cells隱窩增生和杯狀細(xì)胞缺失（三）腸腺腺瘤形成。Branching proliferating crypts分支和增生的隱窩Dilated and branching crypts, very few goblet cells擴張和分支的隱窩，少量杯狀細(xì)胞Proliferative Enteritis增生性腸炎Fibrinonecrotic colitis纖維壞死性結(jié)腸炎Crypt hyperplasia隱窩肥大Dilated cry

4、pts隱窩擴張Absence of goblet cells杯狀細(xì)胞缺失Ileitis - Hyperplasia of muscular layer of intestine回腸炎小腸肌層肥厚Proliferative enteropathy - crypt hyperplasia增生性腸病隱窩肥大Hyperplastic, dilated crypts肥大，擴張的隱窩Hyperplastic, dilated crypts肥大擴張的隱窩Colon - dilated crypts結(jié)腸擴張的隱窩Hyperplasia, necrosis, and scarring of colonic crypts結(jié)腸隱窩的增生，壞死和瘢痕形成四、鑒別診斷（一）細(xì)菌性腸炎（二）劣質(zhì)飼料引起的腸炎（三）梭菌性腸炎Ileitis 血糞，黑糞豬下痢Ileitis 回腸炎出血纖維壞死性腸炎，隱窩擴張，分支，增生Dilated and branching crypts, very few goblet cells擴張和分支的隱窩，少量杯狀細(xì)胞Proliferative en