Flucytosine-5-Fluorocytosine-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEFlucytosineCat. No.: HY-B0139CAS No.: 2022-85-7Synonyms: 5-Fluorocytosine; NSC 103805; Ro 2-9915分式: CHFNO分量: 129.09作靶點(diǎn): Fungal作通路: Anti-infection儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMS

2、O : 16.67 mg/mL (129.13 mM; Need ultrasonic)H2O : 6.67 mg/mL (51.67 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 7.7465 mL 38.7327 mL 77.4653 mL5 mM 1.5493 mL 7.7465 mL 15.4931 mL10 mM 0.7747 mL 3.8733 mL 7.7465 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥

3、式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 1.67 mg/mL (12.94 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 1.67 mg/mL (12.94 mM);

4、Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 1.67 mg/mL (12.94 mM); Suspended solutionBIOLOGICAL ACTIVITY物活性 Flucytosine（5-Fluorocytosine, 5-FC, Ancobon）是抗真菌化合物。REFERENCES1. Vermes A, et al. Flucytosine: a review of its pharmacology, c

5、linical indications, pharmacokinetics, toxicity and drug interactions. JAntimicrob Chemother. 2000 Aug;46(2):171-9.2. Te Dorsthorst DT, et al. In vitro interaction of flucytosine combined with amphotericin B or fluconazole against thirty-five yeast isolatesdetermined by both the fractional inhibitory concentration index and the response surface approach. Antimicrob AgenMcePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;