基于大分子的腫瘤靶向藥物控釋課件

NorthwesternPolytechnicUniversity基于大分子的藥物控釋腫瘤靶向PolymericTumor-TargetingDrugControlledReleaseNorthwesternPolytechnicUniveDrugLoad裝載定位TargetingDrugRelease釋放DrugLoad裝載定位TargetingDrugRel膠束Micelles樹枝狀聚合物DendrimersLiposomes微脂囊聚合物-藥物偶聯(lián)物Polymer-drugconjugatesDrugLoad裝載膠束Micelles樹枝狀聚合物DendrimersLipo定位主動active被動passiveTargeting配合基-受體Ligand-receptorEPR效應(yīng)EPREffect葉酸cRGD定位主動active被動passiveTargeting配合正常組織癌變部位正常組織癌變部位DrugRelease釋放pH溫度降解磁場UV電場內(nèi)因外因PDEAEMAPNIPAM-s-s-hydrazonebondsDrugRelease釋放pH溫度降解磁場UV電場內(nèi)因外因多層分子設(shè)計MolecularDesign嵌段分子量端基ATRPRAFT點(diǎn)擊化學(xué)超分子星形開環(huán)多層分子設(shè)計MolecularDesign嵌段分子量端基ATumor-TargetingPeptideConjugatedpH-ResponsiveMicellesasaPotentialDrugCarrierforCancerTherapyXiangLanWu,JongHoKimTumor-TargetingPeptideConjugTumor-Targeting,pH-Responsive,andStableUnimolecularMicellesasDrugNanocarriersforTargetedCancerTherapyXiaoqiangYang,JamisonJ.Grailer,SrikanthPillaTumor-Targeting,pH-ResponsivePEG-SS-PPS:Reduction-SensitiveDisulfideBlockCopolymerVesiclesforIntracellularDrugDeliveryXiangLanWu,JongHoKimPEG-SS-PPS:Reduction-SensitivFolate-ConjugatedThermoresponsiveBlockCopolymers:HighlyEfficientConjugationandSolutionSelf-AssemblyPriyadarsiDe,SudershanR.Gondi,andBrentS.SumerlinFolate-ConjugatedThermoresponDevelopmentofmultiple-layerpolymericparticlesfortargetedandcontrolleddrugdeliveryBhanuprasanthKoppolu,MS,MahamRahim,Developmentofmultiple-layerOSiOSiOSiSiOSiOSiSiOSiOSiOSiOSiHSiOSiOSiHOSiOSiHSiOSiHNH2NHNH2NHNH2NHNNH2graftedPNIPAMShellβ-CDbasedHBPCoreThermo-ResponsiveHyperbranchedpoly(β-CD)s-g-PNIPAMOSiOSiOSiSiOSiOSiSiOSiOSiOSiOSThankyou!PolymericTumor-Targ