SR0987-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemESR0987Cat.No.:HY-101454CASNo.:303126-97-8分?式:C??H??ClF?NO?分?量:397.7作?靶點(diǎn):ROR作?通路:MetabolicEnzyme/Protease儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:≥150mg/mL(377.17mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.5145mL12.5723mL25.1446mL5mM0.5029mL2.5145mL5.0289mL10mM0.2514mL1.2572mL2.5145mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemESolubility:≥2.5mg/mL(6.29mM);Clearsolution2.請依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(6.29mM);Clearsolution3.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(6.29mM);ClearsolutionBIOLOGICALACTIVITY?物活性SR0987SR1078的?個(gè)類似物，RORγt的?個(gè)激動(dòng)劑，其EC50值為800nM。SR0987可上調(diào)IL17的表達(dá)且抑制PD-1的表達(dá)。IC50&TargetEC50:800nM(RORγt)[1].體外研究SR0987clearlyshowsaconcentrationdependentinductionofreportergeneexpressionwithanEC50of~800nM.SR0987treatmentresultsinastatisticallysignificantreductionofthesurfaceexpressionofPD-1whereasdesmostroltreatmentshowsnoeffect.TreatmentwithSR0987andordesmosterolresultsinatrendtowardsincreasedIL17production[1].戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?SciAdv.2021Jan22;7(4):eabe4827.?WorldJEmergMed.2022;13(1):32-37.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].ChangMR,etal.SyntheticRORγtAgonistsEnhanceProtectiveImmunity.ACSChemBiol.2016Apr15;11(4):1012-8.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:40