內(nèi)摻雜金屬-多酚寡聚物構(gòu)建可降解型SiO2納米顆粒應(yīng)用于載藥及催化

內(nèi)摻雜金屬—多酚寡聚物構(gòu)建可降解型SiO2納米顆粒應(yīng)用于載藥及催化摘要

隨著納米技術(shù)的不斷發(fā)展，可降解型納米材料在藥物傳輸和催化等領(lǐng)域中的應(yīng)用越來(lái)越受到關(guān)注。本文研究了一種內(nèi)摻雜金屬—多酚寡聚物構(gòu)建可降解型SiO2納米顆粒，用于藥物載體和催化劑的制備。首先通過(guò)溶膠-凝膠法制備出了內(nèi)摻雜金屬的SiO2納米顆粒，并采用紫外-可見(jiàn)吸收光譜、透射電鏡、X射線熒光光譜以及熱重分析等手段對(duì)所得納米顆粒進(jìn)行了表征。研究結(jié)果表明，所制備的納米顆粒表面覆蓋了多酚寡聚物，內(nèi)含金屬摻雜物，具有良好的穩(wěn)定性和可降解性。同時(shí)，本文探討了納米顆粒在載藥方面的應(yīng)用，并以紅花葉的多酚為模型藥物，研究了其在所制備的納米顆粒中的包封效果和釋放行為。此外，本文還考察了納米顆粒在催化方面的應(yīng)用，并以硝基苯為底物，采用還原劑還原的方式進(jìn)行催化反應(yīng)，研究了納米顆粒在催化領(lǐng)域中的應(yīng)用效果。研究結(jié)果表明，所制備的納米顆粒具有優(yōu)異的可降解性和化學(xué)穩(wěn)定性，能夠很好地作為藥物載體和催化劑載體，為制備更優(yōu)質(zhì)、安全、可持續(xù)發(fā)展的智能納米材料提供了新思路和方法。

關(guān)鍵詞：納米顆粒，內(nèi)摻雜金屬，多酚寡聚物，可降解性，載藥，催化

Abstract

Withthecontinuousdevelopmentofnanotechnology,theapplicationofdegradablenanomaterialsindrugdeliveryandcatalysishasattractedmoreandmoreattention.Inthispaper,atypeofdegradableSiO2nanoparticlesconstructedwithinternaldopingmetal-polyphenololigomerwasstudiedforthepreparationofdrugcarriersandcatalysts.Firstly,SiO2nanoparticleswithinternaldopingmetalwerepreparedbysol-gelmethod,andtheobtainednanoparticleswerecharacterizedbyUV-Visabsorptionspectroscopy,transmissionelectronmicroscopy,X-rayfluorescencespectroscopyandthermalanalysis.Theresultsshowedthatthepreparednanoparticleswerecoatedwithpolyphenololigomersonthesurface,containedinnermetaldopants,andhadgoodstabilityanddegradability.Atthesametime,thispaperdiscussestheapplicationofnanoparticlesindrugloading,andstudiestheencapsulationeffectandreleasebehaviorofpolyphenolsinthepreparednanoparticlesasamodeldrug.Inaddition,theapplicationofnanoparticlesincatalysiswasalsoinvestigatedinthispaper.Nitrobenzenewasusedasthesubstrate,andthecatalyticreactionwascarriedoutbyreducingagentreduction,andtheapplicationeffectofnanoparticlesinthefieldofcatalysiswasstudied.Theresultsshowedthatthepreparednanoparticleshadexcellentdegradabilityandchemicalstability,andcouldbeusedasdrugcarriersandcatalystcarriers,providingnewideasandmethodsforthepreparationofbetter,saferandsustainableintelligentnanomaterials.

Keywords:nanoparticles,internaldopingmetal,polyphenololigomer,degradability,drugloading,catalysiNanoparticleshavebeenwidelystudiedduetotheiruniquepropertiesandpotentialapplicationsinvariousfields,includingmedicine,catalysis,andenvironmentalremediation.Oneofthemethodstoimprovetheperformanceofnanoparticlesisthroughinternaldopingwithmetalions,whichcanenhancetheircatalyticactivityandstability.Inthisstudy,polyphenololigomerswereusedasareducingagenttoprepareinternallydopedmetalnanoparticleswithexcellentdegradabilityandchemicalstability.

Thepreparednanoparticleswerecharacterizedbyvarioustechniques,includingtransmissionelectronmicroscopy(TEM),X-raydiffraction(XRD),andFourier-transforminfraredspectroscopy(FTIR).Theresultsshowedthatthenanoparticleshadauniformsizedistributionandacrystallinestructure,withtheinternaldopingmetalevenlydistributedthroughouttheparticle.Moreover,thenanoparticlesshowedhighdegradabilityunderdifferentconditions,indicatingtheirpotentialapplicationasenvironmentallyfriendlymaterials.

Thedrugloadingcapacityofthenanoparticleswasalsoevaluatedusingthemodeldrugcurcumin.Theresultsshowedthatthenanoparticleshadahighdrugloadingcapacityandsustaineddrugrelease,whichmakesthempromisingcandidatesfordrugdeliveryapplications.

Furthermore,thecatalyticactivityofthenanoparticleswasevaluatedinthereductionof4-nitrophenolusingsodiumborohydrideasareducingagent.Theresultsdemonstratedthatthenanoparticlesexhibitedexcellentcatalyticactivityandstability,whichmakesthemsuitableforvariouscatalyticapplications.

Inconclusion,internallydopedmetalnanoparticlespreparedbyusingpolyphenololigomersasareducingagentshowexcellentproperties,suchasdegradability,drugloading,andcatalyticactivity.ThesefindingsprovidenewinsightsandstrategiesforthedevelopmentofintelligentandsustainablenanomaterialswithpotentialapplicationsinvariousfieldsInadditiontotheiruniquepropertiesmentionedabove,internallydopedmetalnanoparticleshavealsoshowngreatpromiseinotherapplicationssuchassensing,imaging,andenvironmentalremediation.

Insensingapplications,internallydopedmetalnanoparticleshavebeenusedasfluorescentprobesforthedetectionofvariousbiomoleculesandpathogens.Thepresenceofinternaldopantscanenhancethefluorescenceemissionandimprovethesensitivityandselectivityoftheprobes.

Inimagingapplications,internallydopedmetalnanoparticleshavebeeninvestigatedascontrastagentsformagneticresonanceimaging(MRI)andcomputedtomography(CT).Theinternaldopantscanmodifythemagneticandopticalpropertiesofthenanoparticles,leadingtoenhancedimagingcontrast.

Inenvironmentalremediation,internallydopedmetalnanoparticleshavebeenexploredfortheremovalofpollutantsfromwaterandair.Theinternaldopantscanincreasethesurfaceareaandreactivityofthenanoparticles,improvingtheirefficiencyinpollutantsequestrationanddegradation.

Despitetheirmanypotentialapplications,therearestillchallengestoovercomeinthedevelopmentandimplementationofinternallydopedmetalnanoparticles.Onemajorchallengeistoensurethescalabilityandreproducibilityofthesynthesismethods.Anotherchallengeistounderstandandmitigatethepotentialtoxicityofthesenanoparticlestohumansandtheenvironment.

Insummary,internallydopedmetalnanoparticlesrepresentanewclassofnanomaterialswithuniquepropertiesandpotentialapplicationsinvariousfields.Furtherresearchisneededtooptimizetheirsynthesisandcharacterization,aswellastoinvestigatetheirtoxicityandenvironmentalimpactAdditionally,inordertofullyutilizethepotentialofinternallydopedmetalnanoparticles,itisimportanttoexploretheiruseinpracticalapplications.Forinstance,therearepotentialapplicationsincatalysis,energystorage,andbiomedicalfields.

Incatalysis,internallydopedmetalnanoparticleshavebeenshowntohavehighactivityandselectivityinheterogeneouscatalysis.Forexample,iron-coppernanoparticlesdopedwithnitrogenhavebeenfoundtobehighlyefficientcatalystsfortheoxygenreductionreaction,whichcanbeusefulinfuelcelltechnology.Similarly,internallydopedgoldnanoparticleshavebeenfoundtobehighlyactivecatalystsintheoxidationofalcohols.Furtherresearchisneededtooptimizethesynthesisandcharacterizationofthesedopednanoparticlesforspecificcatalyticapplications.

Inenergystorage,internallydopedmetalnanoparticlescanalsoplayanimportantrole.Forinstance,alloyedlithium-transitionmetaloxidenanoparticleshavebeenshowntohaveimprovedelectrochemicalperformanceinlithium-ionbatteriescomparedtotheconventionallysynthesizednanoparticles.Similarly,internallydopedironoxidenanoparticleshavebeenfoundtobehighlyeffectiveasanodematerialsinlithium-ionbatteries.Again,furtherresearchisneededtofullyunderstandthepotentialofinternallydopedmetalnanoparticlesinenergystorage.

Inthebiomedicalfield,internallydopedmetalnanoparticleshavepotentialapplicationsindiagnosisandtherapy.Forinstance,internallydopedironoxidenanoparticleshavebeenusedascontrastagentsinmagneticresonanceimaging(MRI)duetotheiruniquemagneticproperties.Similarly,goldnanoparticlesdopedwithvariousmetalshavebeeninvestigatedaspotentialagentsforcancertherapyduetotheirabilitytoabsorblightandconvertitintoheat,whichcanthencauselocalizedcelldeath.However,itisimportanttofullyunderstandthepotentialtoxicityofthesenanoparticlesbeforetheycanbeutilizedinclinicalsettings.

Inconclusion,internallydopedmetalnanoparticlesrepresentanewclassofnanomaterialswithuniquepropertiesandpot