Trelagliptin-succinate-SYR-472-succinate-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETrelagliptin succinateCat. No.: HY-15408ACAS No.: 1029877-94-8Synonyms: SYR-472 succinate分式: CHFNO分量: 475.47作靶點(diǎn): Dipeptidyl Peptidase作通路: Metabolic Enzyme/Protease儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1

2、month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 50 mg/mL (105.16 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.1032 mL 10.5159 mL 21.0318 mL5 mM 0.4206 mL 2.1032 mL 4.2064 mL10 mM 0.2103 mL 1.0516 mL 2.1032 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜?/p>

3、解案，配制前請(qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.26 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.26 mM); Clear solut

4、ion1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.26 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Trelagliptin succinate (SYR-472 succinate)是長(zhǎng)效的DPP-4抑制劑。REFERENCES1. Efficacy of SYR-472 in Subjects With Type 2 Diabetes Mellitus2. Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus3. Long-term Study of SYR-4724. SYR-472 Open-label StudyMcePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;/p>