Azvudine-hydrochloride-RO-0622-hydrochloride-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAzvudine hydrochlorideCat. No.: HY-19314ACAS No.: 1333126-31-0Synonyms: RO-0622 hydrochloride; FNC hydrochloride分式: CHClFNO分量: 322.68作靶點: Reverse Transcriptase; HIV; HBV; HCV作通路: Anti-infection儲存式: Powder -20C 3 years4C 2 yearsI

2、n solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 H2O : 125 mg/mL (387.38 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.0990 mL 15.4952 mL 30.9905 mL5 mM 0.6198 mL 3.0990 mL 6.1981 mL10 mM 0.3099 mL 1.5495 mL 3.0990 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIV

3、ITY物活性 Azvudine (RO-0622) hydrochloride種有效的核苷逆轉(zhuǎn)錄酶抑制劑 (NRTI)，對 HIV、HBV 和 HCV 具有抗病毒活性。Azvudine hydrochloride 對 HIV-1 (EC50s 范為0.036.92 nM) 和 HIV-2（EC50s 范為0.0180.025 nM) 有很強的抑制作。Azvudine hydrochloride 抑制 NRTI 耐藥病毒株。IC50 & Target HIV-1 HIV-20.03-6.92 nM (EC50) 0.018-0.02 nM (EC50)1/2 Master of Small Mo

4、lecules 您邊的抑制劑師www.MedChemE體外研究 Azvudine (RO-0622) hydrochloride displays strong inhibition on wild-type HIV-1IIIB and HIV-1RF with anEC50 ranging from 30 to 110 pM. The EC50 values of Azvudine hydrochloride against HIV-1KM018, HIV-1TC-1 and HIV-1WAN T69N are 6.92, 0.34 and 0.45 nM, respectively. Az

5、vudine is sensitive to NRTIs-resistant strain HIV-174V, PIs-resistant strains HIV-1L10R/M46I/L63P/V82T/I84V and HIV-1RF V82F/184V,and FIs-resistant strain pNL4-3gp41 (36G) V38A/N42T. The EC50 values of Azvudine hydrochloride againstthese resistant strains are 0.11, 0.14, 0.37 and 0.36 nM respectivel

6、y 1.REFERENCES1. Wang RR, et al. Azvudine, a novel nucleoside reverse transcriptase inhibitor showed good drug combination features and betterinhibition on drug-resistant strains than lamivudine in vitro. PLoS One. 2014 Aug 21;9(8):e105617.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-8