抗性糊精對飽食及體重控制的作用課件

Effectofaresistantdextrin

onsatietyandweightmanagement

抗性糊精對飽食與體重控制的作用LaetitiaDeremauxEffectofaresistantdextrin1Studydesign研究設(shè)計(jì)Satiety飽食Hungerfeeling饑餓感Foodintake食物攝入STUDYDESIGN研究設(shè)計(jì)Objectives,Studydescription,Population,Studyproductadministration,Groups,Parameters,Scheduledescription目的、研究描述、人群、研究產(chǎn)品服法、群組、參數(shù)、日程描述RESULTS結(jié)果Satiety,Hungerfeeling,Caloric&Foodintake,Bodyweight,Bodyfat飽食、饑餓感、熱量及食物攝入、體重、體脂CONCLUSION結(jié)論Bodyweight體重Bodyfat體脂Studydesign研究設(shè)計(jì)Satiety飽食Hunge2PartI:StudyDesign第一部分：研究設(shè)計(jì)Studydesign研究設(shè)計(jì)Satiety飽食Hungerfeeling饑餓感Foodintake食物攝入Bodyweight體重Bodyfat體脂PartI:StudyDesignStudydesi3StudydesignObjectives:Evaluationoftheimpactof

aresistantdextrinonsatiety,foodintakeandweightmanagement評價(jià)抗性糊精對飽食、食物攝入和體重控制的影響Evaluationoftheimpactofaresistantdextrin

onhungerfeelingandbodyfat評價(jià)抗性糊精對饑餓感及體脂的影響Studydesign研究設(shè)計(jì)Satiety飽食Hungerfeeling饑餓感Foodintake食物攝入Bodyweight體重Bodyfat體脂StudydesignObjectives:Studyd4Studydescription(研究描述)

Randomized,placebo-controlled,double-blind,parallel,singlecenter 隨機(jī)、安慰劑對照、雙盲、平行、單中心ImplementedinChina在中國實(shí)施Studydesign研究設(shè)計(jì)Satiety飽食Hungerfeeling饑餓感Foodintake食物攝入Bodyweight體重Bodyfat體脂StudydesignStudydesign研究設(shè)計(jì)Satiety飽食Hunge5Population(人群)20healthyoverweightChinesevolunteerspergroup(5groups20volunteers)

每組２０位健康超重中國自愿者（５組ｘ２０自愿者）Menandwomen(50/50)

男性與女性（５０／５０）35to55yearsold

35到55歲Overweight(24BMI28kg/m2);Chinesecut-offpointsforoverweight 超重（24≤身體質(zhì)量指數(shù)≤28公斤／米2）；中國超重切分點(diǎn)Factoryworkers 工廠工人：working7daysaweekatLiPumanufacturingplant

荔浦制造廠每周工作７天eatingatthecanteenateverymeals

每餐在食堂就餐StudydesignStudydesign6Administration

(服法)Twodailyintakesofaresistantdextrinin250mlorangejuice

將抗性糊精融入250毫升橙汁，每天攝取兩次Placeboarm:Orangejuice

安慰劑組：橙汁Treatmentarms:Resistantdextrinatdifferentdosagesinorangejuice

治療組：在橙汁中加入不同劑量的抗性糊精Studydesign研究設(shè)計(jì)Satiety飽食Hungerfeeling饑餓感Foodintake食物攝入Bodyweight體重Bodyfat體脂StudydesignAdministration(服法)Studydesi7Parallelstudy(平行研究)Group1:Placebo

組1：安慰劑Group2:4gresistantdextrin2intakes=8g/day

組2：4克抗性糊精2次攝?。?克／天Group3:7gresistantdextrin2intakes=14g/day

組3：7克抗性糊精2次攝取

＝14克／天Group4:9gresistantdextrin2intakes=18g/day

組4：9克抗性糊精2次攝取

＝18克／天Group5:12gresistantdextrin2intakes=24g/day

組5：12克抗性糊精2次攝取

＝24克／天Studydesign研究設(shè)計(jì)Satiety飽食Hungerfeeling饑餓感Foodintake食物攝入Bodyweight體重Bodyfat體脂StudydesignStudydesign研究設(shè)計(jì)Satiety飽食Hunge8ScheduledescriptionBreakfast7:00amLunch12:00-12:30pmDinner6:30pmPlaceboorresistantdextrinPlaceboorresistantdextrin10:00am4:00pmHungerfeelingquestionnaire(9:50am)Hungerfeelingquestionnaire(3:50pm)Satietyevaluation(VAS)from10:00amto12:00amSatietyevaluation(VAS)from4:00pmto6:00pmFoodintakeevaluation(*)(*)(*)(*)Studydesign研究設(shè)計(jì)Satiety飽食Hungerfeeling饑餓感Foodintake食物攝入Bodyweight體重Bodyfat體脂StudydesignScheduledescriptionBreakfast79PartII:Results第二部分:結(jié)果Satiety

飽食Hungerfeeling

饑餓感Foodintake

食物攝入Bodyweight

體重Bodyfat

體脂Studydesign研究設(shè)計(jì)Satiety飽食Hungerfeeling饑餓感Foodintake食物攝入Bodyweight體重Bodyfat體脂PartII:ResultsSatiety飽食Stu10SatietyevaluationbyVAS

飽食評價(jià)（按視覺模擬評分法）Theresistantdextrinhasapositiveandsignificantimpactonsatietyjustafterthefirstconsumptionat14g,18gand24g/day.在首次攝取14克、18克和24克／天后，抗性糊精對飽食有積極且明顯的影響。DAY0OrangejuiceconsumptionHungerfeeling饑餓感Foodintake食物攝入Bodyweight體重Bodyfat體脂Studydesign研究設(shè)計(jì)Satiety飽食SatietyevaluationbyVAS

飽食評價(jià)11SatietyevaluationbyVAS

飽食評價(jià)（按視覺模擬評分法）DAY21Fromday0today21,theresistantdextrinhasshownaprogressiveandstrongimpactonsatiety.Atday21andbeforeday21,theresistantdextrinhasshownasignificantmodulationofsatietyat8g,14g,18gand24g/day.從首日到第21日，抗性糊精已顯示出對飽食有漸進(jìn)及較強(qiáng)的影響。在第21日及之前，每日攝取8克、14克。18克及24克/天，抗性糊精已顯示出對飽食有明顯的調(diào)節(jié)作用。OrangejuiceconsumptionHungerfeeling饑餓感Foodintake食物攝入Bodyweight體重Bodyfat體脂Studydesign研究設(shè)計(jì)Satiety飽食SatietyevaluationbyVAS

飽食評價(jià)12SatietyevaluationbyVAS

飽食評價(jià)（按視覺模擬評分法）Theeffectoftheresistantdextrinonsatietyistimecorrelatedandtheeffectsareclearfromday0.抗性糊精對飽食的作用與時(shí)間相關(guān)，且從首日開始有作用。OrangejuiceconsumptionHungerfeeling饑餓感Foodintake食物攝入Bodyweight體重Bodyfat體脂Studydesign研究設(shè)計(jì)Satiety飽食SatietyevaluationbyVAS

飽食評價(jià)13Theconsumptionoftheresistantdextrinhasapositiveimpactonthehungerfeelingscoreoverthestudyperiodwithastatisticaldifferencefromday5.在研究期間，使用抗性糊精饑餓感評分有正面影響，從第５天起有差異。Foodintake食物攝入Bodyweight體重Bodyfat體脂Studydesign研究設(shè)計(jì)Satiety飽食Hungerfeeling饑餓感Hungerfeeling

饑餓感Theconsumptionoftheresista14Hungerfeeling

饑餓感Thenumberofvolunteers,whoarenothungry,hasincreasedoverthestudyperiodwithadose-effectrelation.不餓的自愿者人數(shù)在研究期間增加，具有量效關(guān)系。Foodintake食物攝入Bodyweight體重Bodyfat體脂Studydesign研究設(shè)計(jì)Satiety飽食Hungerfeeling饑餓感Hungerfeeling

饑餓感Thenumbero15Foodintake

食物攝入Theresistantdextrinhasshownasignificantdecreaseinfoodintakeatlunchoverthestudyperiod,fromweek3.從第３周期，抗性糊精在研究期間明顯減少午餐食物攝入量．Bodyweight體重Bodyfat體脂Studydesign研究設(shè)計(jì)Satiety飽食Foodintake食物攝入Hungerfeeling饑餓感Foodintake

食物攝入Theresistant16Body

weight

體重Theresistantdextrinhasshownasignificantdecreaseinbodyweightfrom-0.42kgat14g/day.Thisweightlostbecamehigherwiththeincreaseofthedosageoftheresistantdextrin.用量為１４克／天時(shí)，抗性糊精明顯減少體重0.42公斤起。隨著抗性糊精用量增加，減重更大。Bodyfat體脂Studydesign研究設(shè)計(jì)Satiety飽食Hungerfeeling饑餓感Foodintake食物攝入Bodyweight體重Bodyweight

體重Theresistantde17Bodyfat

體脂Theresistantdextrinhasshownasignificantdecreaseinbodyfatfrom-0.12%at18g/day.Thisbodyfatdecreasebecamehigherwiththeincreaseofthedosageoftheresistantdextrin.用量為１８克／天時(shí)，抗性糊精明顯減少體重０.１２％起。隨著抗性糊精用量增加，體脂繼續(xù)減少。Studydesign研究設(shè)計(jì)Satiety飽食Hungerfeeling饑餓感Foodintake食物攝入Bodyweight體重Bodyfat體脂Bodyfat

體脂Theresistantdextr18PartIII:Conclusion第三部分：結(jié)論Studydesign研究設(shè)計(jì)Satiety飽食Hungerfeeling饑餓感Foodintake食物攝入Bodyweight體重Bodyfat體脂PartIII:ConclusionStudydesi19ConclusionSThereisalogicalcorrelationbetweenthebiomarkersleadingtoanoverallimprovementThedailyinclusionoftheresistantdextrin

inducesaprogressiveimpactonsatiety,inducingpositiveeffectsonthedecreaseofthefoodintake,withadirectimpactonthemanagementofbodyweightandbodyfat.Thisstudyshowsacleardose-effectrelation造成整體改進(jìn)的生物標(biāo)志物之間存在邏輯相關(guān)性日常攝取抗性糊精對飽食產(chǎn)生漸進(jìn)影響，對食物攝入的減少產(chǎn)生積極的作用，對控制體重和體脂有直接影響。本研究顯示出清晰的量效關(guān)系Studydesign研究設(shè)計(jì)Satiety飽食Hungerfeeling饑餓感Foodintake食物攝入Bodyweight體重Bodyfat體脂ConclusionSThereisalogical20TheRESISTANTDEXTRINhasdemonstratedstrongeffectsinsatietyandweightmanagement抗性糊精飽食和體重控制具有強(qiáng)效ConclusionSStudydesign研究設(shè)計(jì)Satiety飽食Hungerfeeling饑餓感Foodintake食物攝入Bodyweight體重Bodyfat體脂TheRESISTANTDEXTRINhasdemo21Effectofaresistantdextrin

onsatietyandweightmanagement

抗性糊精對飽食與體重控制的作用LaetitiaDeremauxEffectofaresistantdextrin22Studydesign研究設(shè)計(jì)Satiety飽食Hungerfeeling饑餓感Foodintake食物攝入STUDYDESIGN研究設(shè)計(jì)Objectives,Studydescription,Population,Studyproductadministration,Groups,Parameters,Scheduledescription目的、研究描述、人群、研究產(chǎn)品服法、群組、參數(shù)、日程描述RESULTS結(jié)果Satiety,Hungerfeeling,Caloric&Foodintake,Bodyweight,Bodyfat飽食、饑餓感、熱量及食物攝入、體重、體脂CONCLUSION結(jié)論Bodyweight體重Bodyfat體脂Studydesign研究設(shè)計(jì)Satiety飽食Hunge23PartI:StudyDesign第一部分：研究設(shè)計(jì)Studydesign研究設(shè)計(jì)Satiety飽食Hungerfeeling饑餓感Foodintake食物攝入Bodyweight體重Bodyfat體脂PartI:StudyDesignStudydesi24StudydesignObjectives:Evaluationoftheimpactof

aresistantdextrinonsatiety,foodintakeandweightmanagement評價(jià)抗性糊精對飽食、食物攝入和體重控制的影響Evaluationoftheimpactofaresistantdextrin

onhungerfeelingandbodyfat評價(jià)抗性糊精對饑餓感及體脂的影響Studydesign研究設(shè)計(jì)Satiety飽食Hungerfeeling饑餓感Foodintake食物攝入Bodyweight體重Bodyfat體脂StudydesignObjectives:Studyd25Studydescription(研究描述)

Randomized,placebo-controlled,double-blind,parallel,singlecenter 隨機(jī)、安慰劑對照、雙盲、平行、單中心ImplementedinChina在中國實(shí)施Studydesign研究設(shè)計(jì)Satiety飽食Hungerfeeling饑餓感Foodintake食物攝入Bodyweight體重Bodyfat體脂StudydesignStudydesign研究設(shè)計(jì)Satiety飽食Hunge26Population(人群)20healthyoverweightChinesevolunteerspergroup(5groups20volunteers)

每組２０位健康超重中國自愿者（５組ｘ２０自愿者）Menandwomen(50/50)

男性與女性（５０／５０）35to55yearsold

35到55歲Overweight(24BMI28kg/m2);Chinesecut-offpointsforoverweight 超重（24≤身體質(zhì)量指數(shù)≤28公斤／米2）；中國超重切分點(diǎn)Factoryworkers 工廠工人：working7daysaweekatLiPumanufacturingplant

荔浦制造廠每周工作７天eatingatthecanteenateverymeals

每餐在食堂就餐StudydesignStudydesign27Administration

(服法)Twodailyintakesofaresistantdextrinin250mlorangejuice

將抗性糊精融入250毫升橙汁，每天攝取兩次Placeboarm:Orangejuice

安慰劑組：橙汁Treatmentarms:Resistantdextrinatdifferentdosagesinorangejuice

治療組：在橙汁中加入不同劑量的抗性糊精Studydesign研究設(shè)計(jì)Satiety飽食Hungerfeeling饑餓感Foodintake食物攝入Bodyweight體重Bodyfat體脂StudydesignAdministration(服法)Studydesi28Parallelstudy(平行研究)Group1:Placebo

組1：安慰劑Group2:4gresistantdextrin2intakes=8g/day

組2：4克抗性糊精2次攝?。?克／天Group3:7gresistantdextrin2intakes=14g/day

組3：7克抗性糊精2次攝取

＝14克／天Group4:9gresistantdextrin2intakes=18g/day

組4：9克抗性糊精2次攝取

＝18克／天Group5:12gresistantdextrin2intakes=24g/day

組5：12克抗性糊精2次攝取

＝24克／天Studydesign研究設(shè)計(jì)Satiety飽食Hungerfeeling饑餓感Foodintake食物攝入Bodyweight體重Bodyfat體脂StudydesignStudydesign研究設(shè)計(jì)Satiety飽食Hunge29ScheduledescriptionBreakfast7:00amLunch12:00-12:30pmDinner6:30pmPlaceboorresistantdextrinPlaceboorresistantdextrin10:00am4:00pmHungerfeelingquestionnaire(9:50am)Hungerfeelingquestionnaire(3:50pm)Satietyevaluation(VAS)from10:00amto12:00amSatietyevaluation(VAS)from4:00pmto6:00pmFoodintakeevaluation(*)(*)(*)(*)Studydesign研究設(shè)計(jì)Satiety飽食Hungerfeeling饑餓感Foodintake食物攝入Bodyweight體重Bodyfat體脂StudydesignScheduledescriptionBreakfast730PartII:Results第二部分:結(jié)果Satiety

飽食Hungerfeeling

饑餓感Foodintake

食物攝入Bodyweight

體重Bodyfat

體脂Studydesign研究設(shè)計(jì)Satiety飽食Hungerfeeling饑餓感Foodintake食物攝入Bodyweight體重Bodyfat體脂PartII:ResultsSatiety飽食Stu31SatietyevaluationbyVAS

飽食評價(jià)（按視覺模擬評分法）Theresistantdextrinhasapositiveandsignificantimpactonsatietyjustafterthefirstconsumptionat14g,18gand24g/day.在首次攝取14克、18克和24克／天后，抗性糊精對飽食有積極且明顯的影響。DAY0OrangejuiceconsumptionHungerfeeling饑餓感Foodintake食物攝入Bodyweight體重Bodyfat體脂Studydesign研究設(shè)計(jì)Satiety飽食SatietyevaluationbyVAS

飽食評價(jià)32SatietyevaluationbyVAS

飽食評價(jià)（按視覺模擬評分法）DAY21Fromday0today21,theresistantdextrinhasshownaprogressiveandstrongimpactonsatiety.Atday21andbeforeday21,theresistantdextrinhasshownasignificantmodulationofsatietyat8g,14g,18gand24g/day.從首日到第21日，抗性糊精已顯示出對飽食有漸進(jìn)及較強(qiáng)的影響。在第21日及之前，每日攝取8克、14克。18克及24克/天，抗性糊精已顯示出對飽食有明顯的調(diào)節(jié)作用。OrangejuiceconsumptionHungerfeeling饑餓感Foodintake食物攝入Bodyweight體重Bodyfat體脂Studydesign研究設(shè)計(jì)Satiety飽食SatietyevaluationbyVAS

飽食評價(jià)33SatietyevaluationbyVAS

飽食評價(jià)（按視覺模擬評分法）Theeffectoftheresistantdextrinonsatietyistimecorrelatedandtheeffectsareclearfromday0.抗性糊精對飽食的作用與時(shí)間相關(guān)，且從首日開始有作用。OrangejuiceconsumptionHungerfeeling饑餓感Foodintake食物攝入Bodyweight體重Bodyfat體脂Studydesign研究設(shè)計(jì)Satiety飽食SatietyevaluationbyVAS

飽食評價(jià)34Theconsumptionoftheresistantdextrinhasapositiveimpactonthehungerfeelingscoreoverthestudyperiodwithastatisticaldifferencefromday5.在研究期間，使用抗性糊精饑餓感評分有正面影響，從第５天起有差異。Foodintake食物攝入Bodyweight體重Bodyfat體脂Studydesign研究設(shè)計(jì)Satiety飽食Hungerfeeling饑餓感Hungerfeeling

饑餓感Theconsumptionoftheresista35Hungerfeeling

饑餓感Thenumberofvolunteers,whoarenothungry,hasincreasedoverthestudyperiodwithadose-effectrelation.不餓的自愿者人數(shù)在研究期間增加，具有量效關(guān)系。Foodintake食物攝入Bodyweight體重Bodyfat體脂Studydesign研究設(shè)計(jì)Satiety飽食Hungerfeeling饑餓感Hungerfeeling

饑餓感Thenumbero36Foodintake

食物攝入Theresistantdextrinhasshownasignificantdecreaseinfoodintakeatlunchoverthestudyperiod,fromweek3.從第３周期，抗性糊精在研究期間明顯減少午餐食物攝入量．Bodyweight體重Bodyfat體脂Studydesign研究設(shè)計(jì)Satiety飽食Foodintake食物攝入Hungerfeeling饑餓感Foodintake

食物攝入Theresistant37Body

weight

體重Theresistantdextrinhasshownasignificantdecreaseinbodyweightfrom-0.42kgat14g/day.Thisweightlostbecamehigherwiththeincreaseofthedosageoftheresistantdextrin.用量為１４克／天時(shí)，抗性糊精明顯減少體重0.42公斤起。隨著抗性糊精用量增加，減重更大。Bodyfat體脂Studydes