醫(yī)學(xué)專題-肝細(xì)胞癌中表達(dá)

TheClinicalSignificanceofNuclearYAPExpressioninHepatocellularCarcinoma徐智南京醫(yī)科大學(xué)附屬南京第一醫(yī)院暨南京市第一醫(yī)院腫瘤(zhǒngliú)內(nèi)科第一頁(yè)，共十四頁(yè)。1編輯課件WorldwideincidenceofHCCBlumHE,SpangenbergHC.ArchIranMed.2007Jul;10(3):361-71.第二頁(yè)，共十四頁(yè)。編輯課件IdentificationofYes-associatedProtein(YAP)Zender,L.etal.

Cell125,1253-67EFGH第三頁(yè)，共十四頁(yè)。編輯課件YAPimprovescellproliferationTime(Days)*：p<0.05。第四頁(yè)，共十四頁(yè)。編輯課件YAPinducesanchorage-independentgrowthMIHA-YAPcellsbutnotMIHA-Veccouldformcoloniesinsoft-agar.第五頁(yè)，共十四頁(yè)。編輯課件MIHA-YAP

cellsgainedadvantagesincellmigrationandinvasion.YAPenhancescellularmobilityandinvasiveness第六頁(yè)，共十四頁(yè)。編輯課件IHCresultsofYAPinHCC53.7%HCCsamplesshowednuclearYAPpositive.第七頁(yè)，共十四頁(yè)。編輯課件ClinicalassociationofnuclearYAPinHCC第八頁(yè)，共十四頁(yè)。編輯課件ClinicalassociationofnuclearYAPandHCC-specificpostsurgicalrecurrenceKaplan-MeierMedianRFT：NuclearYAPnegative:25.8monthsvs.NuclearYAPpositive：12.9

months第九頁(yè)，共十四頁(yè)。編輯課件NuclearYAPisanindependentprognosticmarkerforHCCrecurrenceCoxRegression第十頁(yè)，共十四頁(yè)。編輯課件SummaryYAPconferstumorigenicandmetastaticpotentialsinhepatocytes,asevidencedbyenhancedaptitudesincellviability,anchorage-independentgrowth,migrationandinvasion.YAPnuclearaccumulationwasfoundinthe53.7%ofHCC,correlatedwithpoorertumordifferentiationandhigherserumalpha-fetoprotein(AFP)levels.NuclearYAPisanindependentpredictorforHCC-specificrecurrence-freesurvival.YAPplaysanimportantroleinHCCdevelopmentandprogression.第十一頁(yè)，共十四頁(yè)。編輯課件Acknowledgement新加坡國(guó)立大學(xué)外科系和藥學(xué)系A(chǔ)sso.Prof.JohnM.Luk香港大學(xué)外科系Prof.FanS.T.，Prof.PoonR.T.

andSurgicalTissueBank南京市第一醫(yī)院腫瘤(zhǒngliú)內(nèi)科第十二頁(yè)，共十四頁(yè)。編輯課件ThankYou第十三頁(yè)，共十四頁(yè)。編輯課件內(nèi)容(nèiróng)總結(jié)TheClinicalSignificanceofNuclearYAPExpressioninHepatocellularCarcinoma。Identif