歐蘭寧奧氮平片說明書

本文格式為Word版，下載可任意編輯——歐蘭寧奧氮平片說明書1?EfficacywasestablishedwithSymbyax(olanzapineandHIGHLIGHTSOFPRESCRIBINGINATIONfluoxetineincombination)inadults;refertotheproductlabelThesehighlightsdonotincludealltheinationneededtouseforSymbyax.ZYPREXAsafelyandeffectively.SeefullprescribinginationforZYPREXA.DOSAGEANDADMINISTRATIONZYPREXA(olanzapine)TabletforOraluseZYPREXAZYDIS(olanzapine)Tablet,OrallyDisintegratingforOraluseZYPREXAIntraMuscular(olanzapine)Injection,Powder,ForSolutionforIntramuscularuseInitialU.S.Approval:1996WARNING:INCREASEDMORTALITYINELDERLYPATIENTSWITHDEMENTIA-RELATEDPSYCHOSISSeefullprescribinginationforcompleteboxedwarning.?Elderlypatientswithdementia-relatedpsychosistreatedwithantipsychoticdrugsareatanincreasedriskofdeath.ZYPREXAisnotapprovedforthetreatmentofpatientswithdementia-relatedpsychosis.(5.1,5.12,17.2)WhenusingZYPREXAandfluoxetineincombination,alsorefertotheBoxedWarningsectionofthepackageinsertforSymbyax.RECENTMAJORCHANGESWarningsandPrecautions:MetabolicChanges(5.4)12/2022OrthostaticHypotension(5.6)MM/YYYYHyperprolactinemia(5.13)12/2022INDICATIONSANDUSAGEZYPREXA?(olanzapine)isanatypicalantipsychoticindicated:Asoralulationforthe:?Treatmentofschizophrenia.(1.1)?Adults:Efficacywasestablishedinthreeclinicaltrialsinpatientswithschizophrenia:two6-weektrialsandonemaintenancetrial.(14.1)?Adolescents(ages13-17):Efficacywasestablishedinone6-weektrialinpatientswithschizophrenia(14.1).Theincreasedpotential(inadolescentscomparedwithadults)forweightgainanddyslipidemiamayleadclinicianstoconsiderprescribingotherdrugsfirstinadolescents.(1.1)?AcutetreatmentofmanicormixedepisodesassociatedwithbipolarIdisorderandmaintenancetreatmentofbipolarIdisorder.(1.2)?Adults:EfficacywasestablishedinthreeclinicaltrialsinpatientswithmanicormixedepisodesofbipolarIdisorder:two3-to4-weektrialsandonemaintenancetrial.(14.2)?Adolescents(ages13-17):Efficacywasestablishedinone3-weektrialinpatientswithmanicormixedepisodesassociatedwithbipolarIdisorder(14.2).Theincreasedpotential(inadolescentscomparedwithadults)forweightgainanddyslipidemiamayleadclinicianstoconsiderprescribingotherdrugsfirstinadolescents.(1.2)?MedicationtherapyforpediatricpatientswithschizophreniaorbipolarIdisordershouldbeundertakenonlyafterathoroughdiagnosticuationandwithcarefulconsiderationofthepotentialrisks.(1.3)?AdjuncttovalproateorlithiuminthetreatmentofmanicormixedepisodesassociatedwithbipolarIdisorder.(1.2)?Efficacywasestablishedintwo6-weekclinicaltrialsinadults(14.2).Maintenanceefficacyhasnotbeensystematicallyuated.AsZYPREXAIntraMuscularforthe:?TreatmentofacuteagitationassociatedwithschizophreniaandbipolarImania.(1.4)?Efficacywasestablishedinthree1-daytrialsinadults.(14.3)AsZYPREXAandFluoxetineinCombinationforthe:?TreatmentofdepressiveepisodesassociatedwithbipolarIdisorder.(1.5)?EfficacywasestablishedwithSymbyax(olanzapineandfluoxetineincombination);refertotheproductlabelforSymbyax.?Treatmentoftreatmentresistantdepression.(1.6)Schizophreniainadults(2.1)Oral:Startat5-10mgoncedaily;Target:10mg/daywithinseveraldaysSchizophreniainadolescents(2.1)Oral:Startat2.5-5mgoncedaily;Target:10mg/dayBipolarIDisorder(manicormixedepisodes)inadults(2.2)Oral:Startat10or15mgoncedailyBipolarIDisorder(manicormixedepisodes)inadolescents(2.2)Oral:Startat2.5-5mgoncedaily;Target:10mg/dayBipolarIDisorder(manicormixedepisodes)withlithiumorvalproateinadults(2.2)Oral:Startat10mgoncedailyAgitationassociatedwithSchizophreniaandBipolarIManiainadults(2.4)IM:10mg(5mgor7.5mgwhenclinicallywarranted)Assessfororthostatichypotensionpriortosubsequentdosing(max.3doses2-4hrsapart)DepressiveEpisodesassociatedwithBipolarIDisorderinadults(2.5)Oralincombinationwithfluoxetine:Startat5mgoforalolanzapineand20mgoffluoxetineoncedailyDepressiveEpisodesassociatedwithBipolarIDisorderinchildrenandadolescents(2.5)Oralincombinationwithfluoxetine:Startat2.5mgoforalolanzapineand20mgoffluoxetineoncedailyTreatmentResistantDepressioninadults(2.6)Oralincombina