Tolterodine-R-plus-Tolterodine-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETolterodineCat. No.: HY-A0024CAS No.: 124937-51-5Synonyms: (R)-(+)-Tolterodine; (+)-Tolterodine; (R)-Tolterodine; PNU-200583分式: CHNO分量: 325.49作靶點: mAChR作通路: GPCR/G Protein; Neuronal Signaling儲存式: Pure form -20C 3 years4C 2 years

2、In solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 14.29 mg/mL (43.90 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.0723 mL 15.3615 mL 30.7229 mL5 mM 0.6145 mL 3.0723 mL 6.1446 mL10 mM 0.3072 mL 1.5361 mL 3.0723 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動

3、物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 1.43 mg/mL (4.39 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 1.43 mg/mL (4.39 mM)

4、; Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Tolterodine(PNU-200583)是毒蕈堿型受體（mAChR）拮抗劑。REFERENCES1. Nilvebrant L. Tolterodine and its active 5-hydroxymethyl metabolite: pure muscarinic receptor antagonists. Pharmacol Toxicol. 2002May;90(5):260-7.2. Andersson

5、 SH, et al. Biotransformation of tolterodine, a new muscarinic receptor antagonist, in mice, rats, and dogs. Drug MetabDispos. 1998 Jun;26(6):528-35.3. Cappon GD, et al. Tolterodine does not affect memory assessed by passive-avoidance response test in mice. Eur J Pharmacol. 2008Jan 28;579(1-3):225-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021