精子DNA損傷與優(yōu)生課件

精子DNA損傷與優(yōu)生Evaluadononly.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyL精子DNA損傷與優(yōu)生1優(yōu)良的精子優(yōu)良的卵子優(yōu)質(zhì)的胚胎Evaluadononly.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyL優(yōu)良的精子2seminiferoustubulerossseTestisEpididymisSeminiferoustubulenolandPrimaryspermatocyte(inprophaseofmeiosis1)na2asocevs(haploidsimal部“天Evaluadononly.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyLseminiferoustubule3AcrosomePlasmamembraneAxialfiamentMitochondriaCentrioleTerminaldisHeadMid(conecting)pieceEvaluadononly.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyLAcrosome4stirPicsWMGLEKOSPERMDEVELOPMENTREQUIRES74DAYSFROMSTARTTOFINISHTHEREFORE,ALLCHEMICALEXPOSURESEXPERIENCEDBYTHEMANLOMALCOHOLTOPESTICIDES)AVETHEABILITYTOWEAKENORDAMAGETHISPROCESS.THEREBYRESULTINGINOFFSPRINGOFLOWEREDGENETICPOTENTIALPringEvaluadononly.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyLstirPics5Primordialgermcell(PGc)GonocyteTypeASpermatogonia-CyclingstemcollPloidy2nSpcntermediateSpermatogoniaTypeBSpermatogonia-SpermatocyteprocursorcollPrimarySpermatocytePloidy4nleptoteneomePairingFirstProphaoePachyteneMeioticDiploteneDivisionMetaphase超品哥SecondSecondarySpermatocyteMeioticolophasobodySpermiogenesisE。gatedspermaticNucleofflagellarintermediatePhagocyte。sedninmanAcrosomeformationbySertolicellsSpermatozoonValadononly.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyLPrimordialgermcell(PGc)6如5epaATGE::::::CA:TGructeuideDNA的分子組成及結(jié)構(gòu)Evaluadononly.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyL如5epa7體細胞與精子DNA的組裝不同DCCAMXnolghyperacetylationdephosphorylationsenecEvaluadononly.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyL體細胞與精子DNA的組裝不同8精子染色體的結(jié)構(gòu)組蛋白為體積更小的魚精蛋白所替代;染色體基本的包裝單位是環(huán)形的環(huán)形包裝單位借助于魚精蛋白上胱氨酸的二硫鍵進一步互相連接,包裝更加緊密;人類的精子染色體殘留有15%的組蛋白魚精蛋白有P1、P2兩種亞型:P2亞型含胱氨酸少;Evaluadononly.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyL精子染色體的結(jié)構(gòu)9優(yōu)質(zhì)精子應(yīng)具備的條件良好的受孕能力遺傳物質(zhì)無異常精子密度正常1、精子DNA完整、未2、精子活力正常;受損傷3、精子形態(tài)正常;2、不攜帶致病基因;4、頂體反應(yīng)能力Evaluadononly.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyL優(yōu)質(zhì)精子應(yīng)具備的條件10精子DNA損傷與優(yōu)生課件11精子DNA損傷與優(yōu)生課件12精子DNA損傷與優(yōu)生課件13精子DNA損傷與優(yōu)生課件14精子DNA損傷與優(yōu)生課件15精子DNA損傷與優(yōu)生課件16精子DNA損傷與優(yōu)生課件17精子DNA損傷與優(yōu)生課件18精子DNA損傷與優(yōu)生課件19精子DNA損傷與優(yōu)生課件20精子DNA損傷與優(yōu)生課件21精子DNA損傷與優(yōu)生課件22精子DNA損傷與優(yōu)生課件23精子DNA損傷與優(yōu)生課件24精子DNA損傷與優(yōu)生課件25精子DNA損傷與優(yōu)生課件26精子DNA損傷與優(yōu)生課件27精子DNA損傷與優(yōu)生課件28精子DNA損傷與優(yōu)生課件29精子DNA損傷與優(yōu)生課件30精子DNA損傷與優(yōu)生課件31精子DNA損傷與優(yōu)生課件32精子DNA損傷與優(yōu)生課件33精子DNA損傷與優(yōu)生課件34精子DNA損傷與優(yōu)生課件35精子DNA損傷與優(yōu)生課件36精子DNA損傷與優(yōu)生課件37精子DNA損傷與優(yōu)生課件38精子DNA損傷與優(yōu)生課件39精子DNA損傷與優(yōu)生課件40精子DNA損傷與優(yōu)生課件41精子DNA損傷與優(yōu)生課件42精子DNA損傷與優(yōu)生課件43精子DNA損傷與優(yōu)生課件44精子DNA損傷與優(yōu)生課件45精子DNA損傷與優(yōu)生課件46精子DNA損傷與優(yōu)生課件47精子DNA損傷與優(yōu)生課件48精子DNA損傷與優(yōu)生課件49精子DNA損傷與優(yōu)生課件50精子DNA損傷與優(yōu)生課件51精子DNA損傷與優(yōu)生Evaluadononly.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyL精子DNA損傷與優(yōu)生52優(yōu)良的精子優(yōu)良的卵子優(yōu)質(zhì)的胚胎Evaluadononly.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyL優(yōu)良的精子53seminiferoustubulerossseTestisEpididymisSeminiferoustubulenolandPrimaryspermatocyte(inprophaseofmeiosis1)na2asocevs(haploidsimal部“天Evaluadononly.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyLseminiferoustubule54AcrosomePlasmamembraneAxialfiamentMitochondriaCentrioleTerminaldisHeadMid(conecting)pieceEvaluadononly.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyLAcrosome55stirPicsWMGLEKOSPERMDEVELOPMENTREQUIRES74DAYSFROMSTARTTOFINISHTHEREFORE,ALLCHEMICALEXPOSURESEXPERIENCEDBYTHEMANLOMALCOHOLTOPESTICIDES)AVETHEABILITYTOWEAKENORDAMAGETHISPROCESS.THEREBYRESULTINGINOFFSPRINGOFLOWEREDGENETICPOTENTIALPringEvaluadononly.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyLstirPics56Primordialgermcell(PGc)GonocyteTypeASpermatogonia-CyclingstemcollPloidy2nSpcntermediateSpermatogoniaTypeBSpermatogonia-SpermatocyteprocursorcollPrimarySpermatocytePloidy4nleptoteneomePairingFirstProphaoePachyteneMeioticDiploteneDivisionMetaphase超品哥SecondSecondarySpermatocyteMeioticolophasobodySpermiogenesisE。gatedspermaticNucleofflagellarintermediatePhagocyte。sedninmanAcrosomeformationbySertolicellsSpermatozoonValadononly.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyLPrimordialgermcell(PGc)57如5epaATGE::::::CA:TGructeuideDNA的分子組成及結(jié)構(gòu)Evaluadononly.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyL如5epa58體細胞與精子DNA的組裝不同DCCAMXnolghyperacetylationdephosphorylationsenecEvaluadononly.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyL體細胞與精子DNA的組裝不同59精子染色體的結(jié)構(gòu)組蛋白為體積更小的魚精蛋白所替代;染色體基本的包裝單位是環(huán)形的環(huán)形包裝單位借助于魚精蛋白上胱氨酸的二硫鍵進一步互相連接,包裝更加緊密;人類的精子染色體殘留有15%的組蛋白魚精蛋白有P1、P2兩種亞型:P2亞型含胱氨酸少;Evaluadononly.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyL精子染色體的結(jié)構(gòu)60優(yōu)質(zhì)精子應(yīng)具備的條件良好的受孕能力遺傳物質(zhì)無異常精子密度正常1、精子DNA完整、未2、精子活力正常;受損傷3、精子形態(tài)正常;2、不攜帶致病基因;4、頂體反應(yīng)能力Evaluadononly.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithA