Sivelestat-EI546-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESivelestatCat. No.: HY-17443CAS No.: 127373-66-4Synonyms: EI546; LY544349; ONO5046分式: CHNOS分量: 434.46作靶點(diǎn): Elastase作通路: Metabolic Enzyme/Protease儲(chǔ)存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fro

2、mlight)溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 100 mg/mL (230.17 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.3017 mL 11.5085 mL 23.0171 mL5 mM 0.4603 mL 2.3017 mL 4.6034 mL10 mM 0.2302 mL 1.1509 mL 2.3017 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適

3、當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.75 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.75 mM); Clear so

4、lution3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (5.75 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Sivelestat(ONO5046; LY544349; EI546)競(jìng)爭(zhēng)性的中性細(xì)胞彈性蛋酶抑制劑，IC50為44 nM，Ki為200nM，還能抑制兔、等的細(xì)胞彈性蛋酶。REFERENCES1. Kawabata K, et al. ONO-5046, a novel inh

5、ibitor of human neutrophil elastase. Biochem Biophys Res Commun. 1991 Jun 14;177(2):814-20.2. Imokawa S, et al. Acute respiratory failure due to pneumocystis pneumonia successfully treated with combined use of sivelestat sodiumhydrate. Nihon Kokyuki Gakkai Zasshi. 2008 Jun;46(6):461-5.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-